Stroke
Pathophysiology, Diagnosis, and Management
6th Edition
Published on 16. September 2015
Book
Hardback
1504 pages
978-0-323-29544-4 (ISBN)
Description
Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors - Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong - head the sixth edition of this classic text, which is authored by the world's foremost stroke experts.
Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.
Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses.
Data from late-breaking endovascular trials equips you with recent findings.
Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy.
Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke.
Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design.
Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography.
Includes extracted and highlighted evidence levels.
Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use.
Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field
Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.
Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses.
Data from late-breaking endovascular trials equips you with recent findings.
Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy.
Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke.
Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design.
Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography.
Includes extracted and highlighted evidence levels.
Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use.
Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field
Reviews / Votes
"Authoritative, eminently readable, and current."-Journal of Neurosurgery"[F]or depth of coverage of individual subjects and as a reference for cerebrovascular diseases, [Stroke] has become the standard."-Annals of Internal Medicine
"Should be part of the libraries of all [those] who deal with cerebrovascular disease." -JAMA
"Updating such a big reference work is a huge task, and by and large the editors have succeeded in their task. They have assembled many very distinguished authors and put together a pretty comprehensive reference work." -Journal of Neurology Neurosurgery and Psychiatry
Reviews of previous edition. "There are sections on pathophysiology, epidemiology, clinical manifestation and individual sections dealing with specific pathological conditions explaining each in great depth. In addition, it has extensive sections devoted to therapy including medical, interventional and surgical. All this makes the book a one-stop-shop for stroke. As a result, it is a work that will prove valuable to a wide range of clinicians involved with providing stroke services, including stroke physicians, acute care physicians, researchers, public health physicians and those involved with rehabilitation medicine...In comparison to the previous editions, the book has definite a advantages in the form of picture quality and web access. It is excellent value for the price as a reference book for stroke, not radiology specific. The book would find its place in a departmental radiology library. Overall, an excellent, up-to-date reference volume." RAD, May 2012
More details
Edition
6th edition
Language
English
Place of publication
Philadelphia
United States
Target group
Professional and scholarly
Illustrations
Approx. 1165 illustrations (up from 812 for the previous edition); Illustrations
Dimensions
Height: 281 mm
Width: 222 mm
Weight
3330 gr
ISBN-13
978-0-323-29544-4 (9780323295444)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
James C. Grotta | Gregory W. Albers | Joseph P. Broderick
Stroke
Pathophysiology, Diagnosis, and Management
Book
07/2021
7th Edition
Elsevier
€235.50
Shipment within 10-15 days
Previous edition
Book
03/2011
5th Edition
Saunders
€377.48
Article exhausted; check for reprint
Persons
Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX Eng H. Lo is a basic neurovascular scientist. He helped develop the neurovascular unit concept (Lo, Nat Rev Neurosci 2003; Tiedt et al, Nat Rev Neurol 2022).
Author
William Leech Professor of Neurosurgery, Newcastle University, UK
Editor
Director, Stroke Program, Memorial Hermann - Texas Medical Center; Professor of Neurology; Chairman, Department of Neurology, University of Texas Medical School at Houston, Houston, TX, USA.
Director, Stanford Stroke Center; Coyote Foundation Professor of Neurology and Neurological Sciences
Director of the Greater Cincinnati-Northern Kentucky Stroke Team; Professor and Chairman, University of Cincinnati, Department of Neurology and Rehabilitation Medicine, Cincinnati, OH
Professor of Neurology at the Hospital of the University of Pennsylvania, Philadelphia, PA
Professor of Neurology and Radiology, Harvard Medical School, Research Staff, Mass General Hospital, Massachusetts General Hospital, Neuroprotection Research Lab, Charlestown, MA, USA
Olemberg Chair of Neurology and Professor of Neurology, Epidemiology and Public Health, Human Genetics, and Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL
Mok Hing Yiu Professor of Medicine, Chief of Neurology, Departments of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, PR China
Content
SECTION I: Pathophysiology
1 Vascular Biology and Atherosclerosis of Cerebral Vessels
2 Mechanisms of Thrombosis and Thrombolysis
3 Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease
4 Histopathology of Brain Tissue Response to Stroke and Injury
5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
6 Intracellular Signaling: Mediators and Protective Responses
7 The Neurovascular Unit and Responses to Ischemia
8 Mechanisms of Cerebral Hemorrhage
9 White Matter Pathophysiology
10 Inflammation and Immune Response
11 Mechanisms of Plasticity, Remodeling and Recovery
12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations
SECTION II: Epidemiology and Risk Factors
13 Global Burden of Stroke
14 Stroke Disparities
15 Modifiable Risk Factors and Determinants of Stroke
16 Prognosis after Stroke
17 Vascular Dementia and Cognitive Impairment
18 Genetic Basis of Stroke Occurrence, Prevention and Outcome
19 Preventing a First Stroke
SECTION III: Clinical Manifestations 20 Classification of Ischemic Stroke
21 Clinical Scales to Assess Patients with Stroke
22 Carotid Artery Disease
23 Anterior Cerebral Artery Disease
24 Middle Cerebral Artery Disease
25 Posterior Cerebral Artery Disease
26 Vertebrobasilar Disease
27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel Disease
28 Intracerebral Hemorrhage
29 Aneurysmal Subarachnoid Hemorrhage
30 Arteriovenous Malformations and Other Vascular Anomalies
31 Stroke and Other Vascular Syndromes of the spinal Cord
SECTION IV: Specific Conditions and Stroke
32 Cardiac Diseases
33 Atherosclerotic Disease of the Proximal Aorta
34 Stroke Related to Surgery and Other Procedures
35 Arterial Dissections and Fibromuscular Dysplasia
36 Collagen Vascular and Infectious Diseases
37 Reversible Cerebral Vasoconstriction Syndromes
38 Hypertensive Encephalopathy
39 Stroke and Substance Abuse
40 Moyamoya Disease
41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
42 Hematologic Disorders and Stroke
43 Migraine and Stroke
44 Cryptogenic Stroke
45 Cerebral Venous Thrombosis
SECTION V: Diagnostic Studies
46 Ultrasonography
47 Computed Tomography-based Evaluation of Cerebrovascular Disease
48 Magnetic Resonance Imaging of Cerebrovascular Diseases
49 Cerebral Angiography
SECTION VI: Therapy
Part A: Medical Therapy
50 Prehospital and Emergency Department Care of the Patient with Acute Stroke
51 Intravenous Thrombolysis
52 Antithrombotic Therapy for Treatment of Acute Ischemic Stroke
53 General Stroke Management and Stroke Units
54 Critical Care of the Patient with Acute Stroke
55 Pharmacologic Modification of Acute Cerebral Ischemia
56 Treatment of "Other" Stroke Etiologies
57 Medical Therapy of Intracerebral and Intraventricular Hemorrhage
58 Rehabilitation and Recovery of the Patient with Stroke
59 Interventions to Improve Recovery after Stroke
60 Enhancing Stroke Recovery with Cellular Therapies
61 Antiplatelet Therapy for Secondary Prevention of Stroke
62 Secondary Prevention of Cardioembolic Stroke
63 Conduct of Stroke-Related Clinical Trials
Part B: Interventional Therapy
64 Endovascular Therapy of Extracranial and Intracranial Occlusive Disease
65 Endovascular Treatment of Acute Ischemic Stroke
66 Endovascular Treatment of Cerebral Aneurysms
67 Interventional Therapy of Brain and Spinal Arteriovenous Malformations
68 Dural Arteriovenous Malformations
Part C: Surgical Therapy
69 Surgery of Anterior and Posterior Aneurysms
70 Surgery for Intracerebral Hemorrhage
71 Intraventricular Hemorrhage
72 Surgical Management of Cranial and Spinal Arteriovenous Malformations
73 Surgical Cavernous Malformations and Venous Anomalies
74 Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis
75 Extracranial to Intracranial Bypass for Cerebral Ischemia
76 Decompressive Craniectomy for Infarction and Hemorrhage
1 Vascular Biology and Atherosclerosis of Cerebral Vessels
2 Mechanisms of Thrombosis and Thrombolysis
3 Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease
4 Histopathology of Brain Tissue Response to Stroke and Injury
5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death
6 Intracellular Signaling: Mediators and Protective Responses
7 The Neurovascular Unit and Responses to Ischemia
8 Mechanisms of Cerebral Hemorrhage
9 White Matter Pathophysiology
10 Inflammation and Immune Response
11 Mechanisms of Plasticity, Remodeling and Recovery
12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations
SECTION II: Epidemiology and Risk Factors
13 Global Burden of Stroke
14 Stroke Disparities
15 Modifiable Risk Factors and Determinants of Stroke
16 Prognosis after Stroke
17 Vascular Dementia and Cognitive Impairment
18 Genetic Basis of Stroke Occurrence, Prevention and Outcome
19 Preventing a First Stroke
SECTION III: Clinical Manifestations 20 Classification of Ischemic Stroke
21 Clinical Scales to Assess Patients with Stroke
22 Carotid Artery Disease
23 Anterior Cerebral Artery Disease
24 Middle Cerebral Artery Disease
25 Posterior Cerebral Artery Disease
26 Vertebrobasilar Disease
27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel Disease
28 Intracerebral Hemorrhage
29 Aneurysmal Subarachnoid Hemorrhage
30 Arteriovenous Malformations and Other Vascular Anomalies
31 Stroke and Other Vascular Syndromes of the spinal Cord
SECTION IV: Specific Conditions and Stroke
32 Cardiac Diseases
33 Atherosclerotic Disease of the Proximal Aorta
34 Stroke Related to Surgery and Other Procedures
35 Arterial Dissections and Fibromuscular Dysplasia
36 Collagen Vascular and Infectious Diseases
37 Reversible Cerebral Vasoconstriction Syndromes
38 Hypertensive Encephalopathy
39 Stroke and Substance Abuse
40 Moyamoya Disease
41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
42 Hematologic Disorders and Stroke
43 Migraine and Stroke
44 Cryptogenic Stroke
45 Cerebral Venous Thrombosis
SECTION V: Diagnostic Studies
46 Ultrasonography
47 Computed Tomography-based Evaluation of Cerebrovascular Disease
48 Magnetic Resonance Imaging of Cerebrovascular Diseases
49 Cerebral Angiography
SECTION VI: Therapy
Part A: Medical Therapy
50 Prehospital and Emergency Department Care of the Patient with Acute Stroke
51 Intravenous Thrombolysis
52 Antithrombotic Therapy for Treatment of Acute Ischemic Stroke
53 General Stroke Management and Stroke Units
54 Critical Care of the Patient with Acute Stroke
55 Pharmacologic Modification of Acute Cerebral Ischemia
56 Treatment of "Other" Stroke Etiologies
57 Medical Therapy of Intracerebral and Intraventricular Hemorrhage
58 Rehabilitation and Recovery of the Patient with Stroke
59 Interventions to Improve Recovery after Stroke
60 Enhancing Stroke Recovery with Cellular Therapies
61 Antiplatelet Therapy for Secondary Prevention of Stroke
62 Secondary Prevention of Cardioembolic Stroke
63 Conduct of Stroke-Related Clinical Trials
Part B: Interventional Therapy
64 Endovascular Therapy of Extracranial and Intracranial Occlusive Disease
65 Endovascular Treatment of Acute Ischemic Stroke
66 Endovascular Treatment of Cerebral Aneurysms
67 Interventional Therapy of Brain and Spinal Arteriovenous Malformations
68 Dural Arteriovenous Malformations
Part C: Surgical Therapy
69 Surgery of Anterior and Posterior Aneurysms
70 Surgery for Intracerebral Hemorrhage
71 Intraventricular Hemorrhage
72 Surgical Management of Cranial and Spinal Arteriovenous Malformations
73 Surgical Cavernous Malformations and Venous Anomalies
74 Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis
75 Extracranial to Intracranial Bypass for Cerebral Ischemia
76 Decompressive Craniectomy for Infarction and Hemorrhage