Tissue Residue Approach for Toxicity Assessment

This book elucidates the scientific underpinnings of the tissue residue approach for toxicity assessment. It demonstrates where data on concentrations of substances of concern in the tissues of exposed organisms add value and reduce or eliminate limitations of traditional approaches for defining risks from chemical contamination. The authors identify where the approach has limitations, provides guidance on how to appropriately apply the approach, and suggests new directions that could provide more sophisticated assessment tools. They explore how monitoring and assessing risks could be improved by applying residue-based concepts to enhance or replace existing approaches.