Enzyme Technologies
Metagenomics, Evolution, Biocatalysis and Biosynthesis
Published on 15. October 2010
Book
Hardback
368 pages
978-0-470-28624-1 (ISBN)
Description
Enzyme Technologies in Drug Discovery highlights how, what, and where enzymes have become critical in pharmaceutical and biotechnology research. This book provides in-depth reviews of recent developments in biosynthesis, biocatalysis, and the chemical biology of enzymes. This text discusses enzymatic assays, including emerging assay technologies for key enzyme classes in pharmaceutical research. In addition to new developments in proteomics, this book includes two emerging technologies in life sciences, metabolomics and preclinomics. This volume reviews important progress on the chemical biology of enzymes in the post-genomic era.
Reviews / Votes
"This book is a coordinated compilation of research expertise and current opinion uniquely focused on enzymes and their properties and applications." (Book Circle, 1 September 2011) "It provides a good starting point and gives all the necessary information to go from the overview of one of the fields described into the details of the broad list of original literature cited." (ChemBioChem, 11 February 2011)More details
Series
Edition
1. Auflage
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Product notice
sewn/stitched
Cloth over boards
Dimensions
Height: 245 mm
Width: 164 mm
Thickness: 27 mm
Weight
692 gr
ISBN-13
978-0-470-28624-1 (9780470286241)
Schweitzer Classification
Other editions
Additional editions
Wu-Kuang Yeh | Hsiu-Chiung Yang | James R. McCarthy
Enzyme Technologies
Metagenomics, Evolution, Biocatalysis and Biosynthesis
E-Book
09/2011
Wiley
€134.99
Available for download
Persons
Wu-Kuang Yeh, PhD, is Executive Consultant and was director of research and principal investigator at PreClinOmics, Inc., from 2004-2010. He was a principal research scientist at Eli Lilly and Company from 1982-2004. He is the author or coauthor of over 115 abstracts and publications, coeditor of one book, and the holder of six U.S. patents.
Hsiu-Chiung Yang, PhD, is a Research Advisor at Eli Lilly and Company.? She was a principal research scientist at Eli Lilly and Company from 1998-2007 and is the author or coauthor of over forty abstracts and publications, as well as co-inventor of one patent.?
James R. Mccarthy, PhD, is the author, coauthor, or coeditor of over 125 scientific publications and holder of over forty U.S. patents. He is on the editorial advisory board of the Journal of Medicinal Chemistry and is a past chair of the division of Medicinal Chemistry of the American Chemical Society. He also serves as a Senior Scientific Advisor for the Huntington Disease Research Foundation.
Content
Contributors. Preface.
PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES.
1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products (Luke A. Moe, Matthew D. McMahon, and Michael G. Thomas).
2 Directed Enzyme and Pathway Evolution (Jacob Vick and Claudia Schmidt-Dannert).
3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs (Laurent Fourage, Celine Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler, and Jean-Marie Sonet).
4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts (Richard J. Fox and Lori Giver).
PART B BIOCATALYTIC APPLICATIONS.
5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients (Animesh Goswami).
6 Enzymatic Processes for the Production of Pharmaceutical Intermediates (David Rozzell and Jim Lalonde).
7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes (Kurt Faber, Silvia M. Glueck, Birgit Seisser, and Wolfgang Kroutil).
PART C BIOSYNTHETIC APPLICATIONS.
8 Drug Discovery and Development by Combinatorial Biosynthesis (Matthew A. DeSieno, Carl A. Denard, and Huimin Zhao).
9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics (Richard H. Baltz, Kien T. Nguyen, and Dylan C. Alexander).
10 Pathway and Enzyme Engineering and Applications for Glycodiversification (Lishan Zhao and Hung-wen Liu).
Index.
PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES.
1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products (Luke A. Moe, Matthew D. McMahon, and Michael G. Thomas).
2 Directed Enzyme and Pathway Evolution (Jacob Vick and Claudia Schmidt-Dannert).
3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs (Laurent Fourage, Celine Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler, and Jean-Marie Sonet).
4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts (Richard J. Fox and Lori Giver).
PART B BIOCATALYTIC APPLICATIONS.
5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients (Animesh Goswami).
6 Enzymatic Processes for the Production of Pharmaceutical Intermediates (David Rozzell and Jim Lalonde).
7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes (Kurt Faber, Silvia M. Glueck, Birgit Seisser, and Wolfgang Kroutil).
PART C BIOSYNTHETIC APPLICATIONS.
8 Drug Discovery and Development by Combinatorial Biosynthesis (Matthew A. DeSieno, Carl A. Denard, and Huimin Zhao).
9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics (Richard H. Baltz, Kien T. Nguyen, and Dylan C. Alexander).
10 Pathway and Enzyme Engineering and Applications for Glycodiversification (Lishan Zhao and Hung-wen Liu).
Index.