Thermodynamics in Biochemistry
Processes, Energetics and Control
Cherif F. Matta(Author)
Wiley-Blackwell (Publisher)
1st Edition
Will be published approx. 2030
Book
Hardback
400 pages
978-3-527-33996-9 (ISBN)
Description
Filling a gap in the literature, this is the first overview of the central metabolism and how it is driven and connected by thermodynamics. It builds on the basics of biochemistry and discusses the ideas at a higher, more specialized conceptually-driven level.
As such this up-to-date book covers the core concepts as they relate to intermediary metabolism, yet, more specifically, focuses on the energy flow in the principal reactions of central metabolism and the energetics of the electron transport chain. The emphasis throughout is on controlling the speed of biochemical reactions through the complex network of positive and negative feedbacks. The book concentrates on particular aspects of metabolism and mammalian physiology to illustrate the logic governing core biological processes, how they are self-sustained, and how they are controlled by energetics, compartmentalization, selection, recognition, and interconnected feedback control loops as a series of well-defined, spatially-bounded but thermodynamically open systems.
A must-read for biochemists and biophysicists wishing to understand the central role of thermodynamics in our bodies.
As such this up-to-date book covers the core concepts as they relate to intermediary metabolism, yet, more specifically, focuses on the energy flow in the principal reactions of central metabolism and the energetics of the electron transport chain. The emphasis throughout is on controlling the speed of biochemical reactions through the complex network of positive and negative feedbacks. The book concentrates on particular aspects of metabolism and mammalian physiology to illustrate the logic governing core biological processes, how they are self-sustained, and how they are controlled by energetics, compartmentalization, selection, recognition, and interconnected feedback control loops as a series of well-defined, spatially-bounded but thermodynamically open systems.
A must-read for biochemists and biophysicists wishing to understand the central role of thermodynamics in our bodies.
More details
Language
English
Place of publication
Berlin
Germany
Publishing group
Wiley-VCH Verlag GmbH
Target group
Professional and scholarly
Illustrations
100 s/w Abbildungen
Dimensions
Height: 244 mm
Width: 170 mm
ISBN-13
978-3-527-33996-9 (9783527339969)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Person
Cherif F. Matta is an Associate Professor at the Department of Chemistry and Physics, Mount Saint Vincent University (MSVU), an Honorary Adjunct Professor at the Department of Chemistry, Dalhousie University, and an Adjunct Professor at the Department of Chemistry, Saint Mary's University (all in Halifax, Canada). He obtained his BSc from Alexandria University, Egypt, in 1987 and gained his PhD in theoretical chemistry from McMaster University, Canada, in 2002. He was then a postdoctoral fellow at the University of Toronto, Canada, before being awarded an I. W. Killam Fellowship at Dalhousie University. In addition to his current academic appointments, which started in 2006, he has held adjunct/visiting Professorships at McMaster University and at the Universite Henri Poincare (UHP), France. In 2009, he completed his habilitation degree from the UHP. In 2010, he was elected as Fellow of the Royal Society of Chemistry (FRSC), he has received the Molecular Graphics and Molecular Simulation Society Silver Jubilee Prize for 2009 and the John C. Polanyi Prize in Chemistry in 2004. His research is in theoretical and computational chemistry with a focus on the analysis of molecular electron densities and its applications.
Content
A Brief Review of Thermodynamics
A Thermodynamic Description of the Living System
Forms of Biochemical Energy and Work
Energy flow in intermediary metabolism
Membrane Thermodynamics and Membrane Potentials: A Prelude to Chemiosmotic Theory
Chemiosmotic Theory
ATP-Synthase, a Biomolecular Machine: Structure, Function, and Dynamics
Selection and Molecular Recognition
Elements of Control and Cybernetics in Biochemical Networks
The Chemical Logic of Metabolism and its Overall Plan
The Contribution of Bioenergetics to the Eternal Emergence vs. Reductionism Debate
So What is Life then Mr. Schroedinger?
A Thermodynamic Description of the Living System
Forms of Biochemical Energy and Work
Energy flow in intermediary metabolism
Membrane Thermodynamics and Membrane Potentials: A Prelude to Chemiosmotic Theory
Chemiosmotic Theory
ATP-Synthase, a Biomolecular Machine: Structure, Function, and Dynamics
Selection and Molecular Recognition
Elements of Control and Cybernetics in Biochemical Networks
The Chemical Logic of Metabolism and its Overall Plan
The Contribution of Bioenergetics to the Eternal Emergence vs. Reductionism Debate
So What is Life then Mr. Schroedinger?