Challenges of Biological Aging
Published on 5. September 2000
Book
Paperback/Softback
220 pages
978-0-8261-0082-5 (ISBN)
Description
This volume provides the non-biologist an overview of what is known about the physiological bases of aging. The author examines the many basic theories and emerging hypotheses underlying the molecular, cellular, and systemic processes involved in senescence. He addresses the normal physiological changes that characterize the aging phenotype, and also considers the role of many age-associated diseases in growing older. Masoro synthesizes a much-needed "unified theory" of biological aging to which explains how and why the body grows into the condition we call "old." This text is intended for gerontology students in training, as well as for human physiologists interested in gerontology,.
More details
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Dimensions
Height: 229 mm
Width: 152 mm
Thickness: 13 mm
Weight
365 gr
ISBN-13
978-0-8261-0082-5 (9780826100825)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Person
Edward J. Masoro, PhD, was the chairman of the UTHSCSA Physiology Department for many years. Currently a professor emeritus, has has served as President of the Gerontological Society of America.
Content
Preface
Acknowledgments
Aging: A Biological Puzzle
The Puzzle
Mortality Risk
Anatomical and Physiological Changes
Age-Associated Diseases
Concept of Biological Age
Genetics
Universality
Demography and the Societal Challenge
Population Mortality Data
Factors Determining Population Age Structure
Societal Impact of Changing Age Structure
Need for Biomedical Breakthroughs
Why Aging Occurs
Evolutionary Biology
History of Evolutionary Theories of Aging
Current Evolutionary Theory of Aging
Genetic Mechanisms in the Evolution of Aging
Evidence Supporting the Evolutionary Theory
How Aging Occurs
Overview
Theories, Hypotheses, and Concepts
Conclusions
Biological Basis of Aging: A Unifying Concept
Evolutionary Theory as a Guide
The Disposable Soma Theory of Aging
"Private" and "Public" Proximate Mechanisms of Aging
Unifying Concept
The Human Aging Phenotype
Body Structure and Composition
Skin
Musculoskeletal System
Nervous System
Cardiovascular System
Respiratory System
Renal and Urinary System
Gastrointestinal System
Endocrine and Metabolic Function
Female Reproductive System
Male Reproductive System
Immune System
Thermoregulation
Possible Interventions to Retard Aging
Dietary Restriction in Rodents
Proposed Pharmacological Interventions
Lifestyle and Environmental Factors
Index
Acknowledgments
Aging: A Biological Puzzle
The Puzzle
Mortality Risk
Anatomical and Physiological Changes
Age-Associated Diseases
Concept of Biological Age
Genetics
Universality
Demography and the Societal Challenge
Population Mortality Data
Factors Determining Population Age Structure
Societal Impact of Changing Age Structure
Need for Biomedical Breakthroughs
Why Aging Occurs
Evolutionary Biology
History of Evolutionary Theories of Aging
Current Evolutionary Theory of Aging
Genetic Mechanisms in the Evolution of Aging
Evidence Supporting the Evolutionary Theory
How Aging Occurs
Overview
Theories, Hypotheses, and Concepts
Conclusions
Biological Basis of Aging: A Unifying Concept
Evolutionary Theory as a Guide
The Disposable Soma Theory of Aging
"Private" and "Public" Proximate Mechanisms of Aging
Unifying Concept
The Human Aging Phenotype
Body Structure and Composition
Skin
Musculoskeletal System
Nervous System
Cardiovascular System
Respiratory System
Renal and Urinary System
Gastrointestinal System
Endocrine and Metabolic Function
Female Reproductive System
Male Reproductive System
Immune System
Thermoregulation
Possible Interventions to Retard Aging
Dietary Restriction in Rodents
Proposed Pharmacological Interventions
Lifestyle and Environmental Factors
Index