GABA in the Nervous System
The View at Fifty Years
Published on 1. September 2000
Book
Hardback
512 pages
978-0-7817-2267-4 (ISBN)
Description
GABA in the Nervous System summarizes recent advances in understanding the role of GABA as a neurotransmitter. First discovered as an inhibitory signal in 1950, GABA may also fulfill a decisive role in diseases such as Parkinson's and Alzheimer's, stroke, and other clinical problems. This book provides a comprehensive understanding of GABA at both the molecular and systemic level. Each chapter provides a balanced view of current knowledge while referencing historical discoveries during the last half-century
GABA in the Nervous System summarizes recent advances in understanding the role of GABA as a neurotransmitter. First discovered as an inhibitory signal in 1950, GABA may also fulfill a decisive role in diseases such as Parkinson's and Alzheimer's, stroke, and other clinical problems. This book provides a comprehensive understanding of GABA at both the molecular and systemic level. Each chapter provides a balanced view of current knowledge while referencing historical discoveries during the last half-century
GABA in the Nervous System summarizes recent advances in understanding the role of GABA as a neurotransmitter. First discovered as an inhibitory signal in 1950, GABA may also fulfill a decisive role in diseases such as Parkinson's and Alzheimer's, stroke, and other clinical problems. This book provides a comprehensive understanding of GABA at both the molecular and systemic level. Each chapter provides a balanced view of current knowledge while referencing historical discoveries during the last half-century
More details
Language
English
Place of publication
Philadelphia
United States
Target group
College/higher education
Professional and scholarly
Illustrations
146 illustrations, 27 tables
Dimensions
Height: 254 mm
Width: 178 mm
Weight
1110 gr
ISBN-13
978-0-7817-2267-4 (9780781722674)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
;Adventures with GABA:Fifty Years On ;Mechanisms Controlling GABA Synthesis and Degradation in the Brain ;Cytoplasmic Membrane Transporters for GABA ;Uptake and Storage of GABA in Synaptic Vesicles ;GABA Chemistry:Analogs of GABA as Therapeutic and Investigational Agents ;Function of GABA Receptors:Insights from Mutant and Knockout Mice ;The Benzodiazepine Site of GABA Receptors ;Pharmacologic Subtypes of GABA Receptors Based on Subunit Composition ;Functional Domains of GABA Receptors ;Kinetic Properties of GABA Receptor Channels ;Alcohol and General Anesthetic Actions on the GABA Receptor ;Regulation of GABA Receptors by Protein Phosphorylation ;Neurosteroids and GABA Receptor Plasticity ;GABA Receptors:Structure and Function ;GABA Emerges as a Developmental Signal during Neurogenesis of the Rat Central Nervous System ;GABA in the Basal Ganglia ;Epilepsy ;GABAergic Interneuronal Networks in the Hippocampus ;GABA Neurons of the Hippocampal Formation:Localization, Vulnerability, and Plasticity ;GABA Neurons of the Neocortex ;GABA Receptor Diversity:A View from the Cerebellum ;GABAergic Inhibition in the Cerebellar System ;Neuromodulation of GABA in Developing and Mature Hypothalamic Neurons ;GABA in the Mammalian Spinal Cord ;GABA in the Retina ;The Role of Glutamic Acid Decarboxylase and GABA in the Pancreas and Diabetes ;Index;;