Polymers in Medicine and Bioengineering
Published on 1. April 2011
Book
Hardback
425 pages
978-0-387-98659-3 (ISBN)
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Description
This text provides students in biomedical engineering with a fundamental understanding of the principles behind the design and engineering of well-defined molecular structures and architectures intended for in vitro functional studies and in vivo biomedical and clinical applications. It assumes no detailed prior knowledge of polymer science, engineering, or molecular biology, as each chapter or section includes boxed explanations as needed and a problem set. After an introductory section, the book goes on to cover the principles and concepts of macromolecular assembly and the structural design of amphiphiles and polymers, a molecular level understanding of tissue-material interactions, structure-function relationships, a state-of-the-art review of polymer design in complex multi-component devices, and pragmatic issues involved in technology transfer.
More details
Language
English
Place of publication
New York, NY
United States
Target group
College/higher education
Graduate
Illustrations
150 s/w Abbildungen, 10 s/w Tabellen
150 black & white illustrations, 10 black & white tables
Dimensions
Height: 235 mm
Width: 155 mm
ISBN-13
978-0-387-98659-3 (9780387986593)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
I. INTRODUCTION. 1. Perspectives: past, present and future. 2. Host response to polymer implants - an overview. II. PHYSICAL AND CHEMICAL BASIS FOR MACROMOLECULAR ASSEMBLY: PRINCIPLES AND CONCEPTS. 3. Intra- and Intermolecular forces. 4. Molecular and Macromolecular assembly. III PHYSICAL AND CHEMICAL BASIS FOR MACROMOLECULAR ASSEMBLY: STRUCTURAL DESIGN OF AMPHIPHILES AND POLYMERS. 5. Synthetic polymers as biomaterials. 6. Synthetic and natural amphiphiles. 7. Cell membranes and the glycocalyx. 8. Connecting structure with function. IV. INTERACTIONS OF BLOOD WITH POLYMER BIOMATERIALS. 9. Hemostasis and thrombosis. 10. Blood compatibility of polymers. 11. Experimental methods for testing blood compatibility. V. INTERACTIONS OF SOFT-TISSUE WITH POLYMER BIOMATERIALS. 12 Inflammation and wound healing. 13. Extracellular matrix. 14. Tissue biocompatibility of polymers. 15. Bacterial adhesion and infection. 15. Experimental methods for testing tissue biocompatibility. VI DESIGNING STRUCTURE AND FUNCTION IN BIOMEDICAL POLYMERS. 17. Polymer Hydrogels and Membranes. 18. Polymer design for tissue engineering. 19. Absorbable polymers. 20. Drug delivery systems. 21. Elastomers and Thermoplastics as cardiovascular implants. 22 Engineering a biocompatible polymer surface or interface. 23. Experimental methods for surface analysis. VII. POLYMERS IN COMPLEX MULTI COMPONENT DEVICES. 24. Cardiopulmonary bypass. 25. Catheters, and intracoronary stents. 26 Vascular grafts, artificial and heart valves. 27. Other systems. VIII. BASIC RESEARCH TO CLINICAL APPLICATION. 28. The Role of the FDA; checks and balances; and biomaterials availability. Index.