Neocarzinostatin
The Past, Present, and Future of Anticancer Drug
Published on 31. December 1996
Book
Hardback
XVI, 287 pages
978-4-431-70187-3 (ISBN)
Description
The 20th century has witnessed the great benefits of the development of antibi otics, which became a reality after World War IL More than 50 years ago I witnessed the miraculous therapeutic power of penicillin, when I was a student at the Tohoku University Medical School's Department of Bacteriology in Sendai, Japan. The late Dr. Kondo was a graduate student in the department at that time and developed the first crude penicillin preparation in Japan which was applied with dramatic results in two patients. Although there was patient-family consent at that time, ethics committees, randomization. mutagenesis tests, distribution studies, purity-criteria, and phar macokinetics were not yet in existence. Today, regulatory procedures have com plicated the whole drug-approval process. For example, any new antibiotics that have been proven effective in laboratory studies against gram-negative bacteria, as might exist in deadly plague bacteria, must still undergo a long and enormously costly regulatory process before they can be introduced to benefit society, and before government insurance can be applied.
More details
Language
English
Place of publication
Tokyo
Japan
Target group
Professional and scholarly
Illustrations
45 s/w Abbildungen, 13 farbige Abbildungen
45 black & white illustrations, 13 colour illustrations, biography
Weight
760 gr
ISBN-13
978-4-431-70187-3 (9784431701873)
DOI
10.1007/978-4-431-66914-2
Schweitzer Classification
Other editions
Additional editions
Hiroshi Maeda | Kiyoto Edo | Nakao Ishida
Neocarzinostatin
The Past, Present, and Future of Anticancer Drug
E-Book
11/2013
Springer
€96.29
Available for download
Hiroshi Maeda | Kiyoto Edo | Nakao Ishida
Neocarzinostatin
The Past, Present, and Future of Anticancer Drug
Book
10/2013
Springer
€106.99
Shipment within 10-15 days
Content
Chemical Structure of the Apoprotein of Neocarzinostatin.- Neocarzinostatin Chromophore: Structure and Mechanism of DNA Cleavage.- Synthesis and Chemistry of Nine-Membered Cyclic Enediyne Chromophores of Chromoprotein Antitumor Antibiotics.- Solution Structure of Neocarzinostatin Determined by Homonuclear Two-Dimensional Nuclear Magnetic Resonance.- Three-Dimensional Structure of Neocarzinostatin.- The Biochemical Mechanisms Involved in the Biological Effects Induced by Neocarzinostatin (NCS) and the NCS Chromophore.- Activation of Neocarzinostatin by NADPH Cytochrome P-450 Reductase: Proposal of an Ultimate Mode of Action in Cells Involving Oxygen Free Radicals.- Immunomodulating Antitumor Mechanisms of SMANCS.- Host-Mediated Antitumor Activity Induced by Neocarzinostatin and Its Polymer-Conjugated Derivative in Tumor-Bearing Mice.- Pharmacological Uniqueness and Clinical Effects of Neocarzinostatin.- Metamorphosis of Neocarzinostatin to SMANCS: Chemistry, Biology, Pharmacology, and Clinical Effect of the First Prototype Anticancer Polymer Therapeutic.- Supplementary Materials: Publications on Neocarzinostatin or Related Subjects, in English, 1960-1981.