DNA Repair and Cancer
From Bench to Clinic
1st Edition
Published on 22. January 2013
Book
Hardback
718 pages
978-1-4665-7743-5 (ISBN)
Description
DNA repair is a rapidly advancing field in biology. DNA repair systems represent a major defense mechanism against environmental and intracellular damaging agents, such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. In particular, it provides essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.
More details
Language
English
Place of publication
Bosa Roca
United States
Publishing group
Taylor & Francis Inc
Target group
College/higher education
Illustrations
56 s/w Abbildungen, 18 farbige Abbildungen
18 Illustrations, color; 56 Illustrations, black and white
Dimensions
Height: 240 mm
Width: 161 mm
Thickness: 43 mm
Weight
1233 gr
ISBN-13
978-1-4665-7743-5 (9781466577435)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
01/2013
CRC Press
€403.99
Available for download
Persons
Srinivasan Madhusudan, David M. Wilson III
Content
Overview of DNA Repair Pathways. Longevity Assurance by Genome Maintenance. Genome Instability of Cancer: Biological Predictions and Clinical Implications. Radiation Induced DNA Damage, Repair and Therapeutics. Chemotherapeutic Alkylating Agents in Cancer Treatment. O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy. DNA Mismatch Repair: It's Role in Human. Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy. DNA Base Excision Repair Therapeutics: Summary of Targets with a Focus on APE1. Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer. Susceptibility. Fanconi Anemia, Interstrand Cross-link Repair and Cancer. Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets. p53 in DNA Damage, Repair and Cancer Therapeutics. ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy. The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy. PARP and PARP Inhibitor Therapeutics. Tumor Genetics and Personalized Medicine. The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment. Early Phase Clinical Trials using DNA Repair Inhibitors: Lessons Learnt.