Current Advances in ACE Inhibition: v.2

Part 1 State of the art: modulation of sympatho-adrenal function by the renin angiotensin system; the interaction of the renin angiotensin system with atrial peptides; the renal effects of ACE inhibition; renoprotective effects of ACE inhibitionC; hypertension and diabetes - familial and environmental factors in the genesis of renovascular complications; renoprotective actions of ACE inhibirots in diabetes mellitus; update on renovascular hypertension; ACE inhibitors - an update on heart failure trials; tissue ACE inhibition in humans; tissue RAS or paracrine RAS?; the actions of angiotensin 2 on vascular tone; indirect actions of angiotensin 2 on vascular tone; role of angiotensin 2 in growth regulation of vascular smooth muscle; effect of ACE inhibition treatment on vascular structure and compliance; therapeutic implications; active and passive response of arterial vasculature to ACE inhibition in human hypertension; the renin angiotensin system, its role in vascular cell growth; the use of transgenes to study the renin angiotensin system - present and future perspective; tissue renin-angiotensin systems - recent advances and new questions; molecular genetics of ACe - clinical implications; renin and prorenin - ounterpoised vasoconstrictor and vasodilator agents?; alternative ways to inhibit the renin angiotensin system - general overview; non peptide angiotensin 2 receptor antagonists; USA.. clinical investigation of renin inhibition; angiotensin 2, aldosterone and the heart - effects on growth and injury; angiotensin converting enzyme inhibitors and regression of left ventricular hypertrophy - is it clinically beneficial?; a role for ACe inhibitors in modulation ventricular remodelling and altering the course of heart dysfunction in ischaemia and myocardial infarction E/ future use of ACE inhibitors. Part 2 Free communications.