Epigenetic Therapy of Cancer
Preclinical Models and Treatment Approaches
Published on 15. January 2014
Book
Hardback
X, 325 pages
978-3-642-38403-5 (ISBN)
Description
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Reviews / Votes
From the reviews:
"This new book covers the timely topic of epigenetic therapy. . The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. . This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy." (Gerd Pfeifer, Doody's Book Reviews, May, 2014)More details
Edition
2014 ed.
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Professional/practitioner
Illustrations
34 s/w Abbildungen, 14 farbige Abbildungen
X, 325 p. 48 illus., 14 illus. in color.
Dimensions
Height: 241 mm
Width: 160 mm
Thickness: 24 mm
Weight
670 gr
ISBN-13
978-3-642-38403-5 (9783642384035)
DOI
10.1007/978-3-642-38404-2
Schweitzer Classification
Other editions
Additional editions
Michael Lübbert | Peter A. Jones
Epigenetic Therapy of Cancer
Preclinical Models and Treatment Approaches
Book
09/2016
Springer
€149.79
Shipment within 7-9 days
Michael Lübbert | Peter A. Jones
Epigenetic Therapy of Cancer
Preclinical Models and Treatment Approaches
E-Book
12/2013
1st Edition
Springer
€96.29
Available for download
Content
The fundamental role of epigenetic regulation for normal and disturbed all growth and differentiation.- Mouse models to study DNA methylation in cancer research.- Epigenetic regulation of normal hematopoietic development.- Epigenetic regulation of globin genes and disturbances in hemoglobinopathies.- DNA methylation abnormalities in hematopoietic disorders: biological significance and methodological approaches.- Epigenetic modifications mediated by the AML1/ETO and MLL leukemia fusion proteins.- Epigenetic abnormalities in lung cancer.- Pharmacodynamic Responses to DNA Methyltransferase Inhibition.- Histone Methyltransferases: Opportunities in Cancer Drug Discovery.- Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.- Clinical Implications of Epigenetic Alterations in Lung Cancer.- Epigenetic disturbances in colorectal cancer.- Epigenetic Therapies in Solid Tumours: from preclinical models to clinical trial results.