Molecular Structure and Energetics
Mechanistic Principles of Enzyme Activity
Published on 27. January 1989
Book
Hardback
XII, 404 pages
978-3-527-26907-5 (ISBN)
Description
An interdisciplinary perspective on mechanistic principles such as the requirements for electron transfer, the role of binding and proximity, stereroelectronic effects, and structural determination of reaction coordinates to fundamental classes of enzymatic reactions.
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Content
Structural Aspects of Zinc Protease Mechanisms; Stereoelectronic Analysis of Enzymatic Reactions; Intramolecularity: Proximity and Strain; Structural and Energetic Aspects of Protolytic Catalysis by Enzymes: Charge-Relay Catalysis in the Function of Serine Proteases; Electron Transfer in Cytochromes C and B; Chemical Studies Related to Iron Protoporphyrin-IX Mixed Function Oxidases; Porphyrin Metalation Reactions in Biochemistry; Chemical Studies and the Mechanism of Flavin and Porphyrin Mixed Function Oxidase Enzymes; Glutahione-Dependent Aldehyde Oxidation Reactions.