Pharmaceutical Process Scale-Up, Second Edition

Dimensional Analysis and Scale-Up in Theory and Industrial Application. Engineering Approaches for Pharmaceutical Process Scale-up, Validation, Optimization, and Control in the PAT Era. Parenteral Drug Scale-Up. Non-Parenteral Liquids and Semi-Solids. Scale-Up Considerations for Biotechnology Derived Products. Batch Size Increase in Dry Blending and Mixing. Batch Size Increase and: Powder Handling. Scale-Up in the Field of Granulation and Drying. Scale-Up of Roller Compaction Process. Batch Size Increase in Fluid Bed Granulation. Scale-Up of Extrusion and Spheronizing. Scale-Up of Compaction and Tableting Process. Practical Considerations in the Scale Up of Powder-Filled Hard Shell Capsule Formulations. Scale-Up of the Film-Coating Process. Innovation and Continuous Improvement in Pharmaceutical Manufacturing. Appendix