
How to Scale-Up a Wet Granulation End Point Scientifically
Volume 1
Michael Levin(Author)
Academic Press
Published on 22. October 2015
Book
Paperback/Softback
88 pages
978-0-12-803522-1 (ISBN)
Description
How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point.
Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.
Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.
More details
Series
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Pharmaceutical personnel from R&D professionals to team leaders and department heads; those working in nutraceutical and generic manufacturing companies
Dimensions
Height: 229 mm
Width: 152 mm
Weight
160 gr
ISBN-13
978-0-12-803522-1 (9780128035221)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Person
Michael Levin has over 30 years of experience in the field of pharmaceutical scale-up, instrumentation and process optimization. He has edited a "Pharmaceutical Process Scale-Up? book, and has contributed chapters on "Tablet Press Instrumentation? and "Wet Granulation: End-Point Determination and Scale-Up? in the Encyclopedia of Pharmaceutical Technology. Michael holds a M.Sc. degree in History and Philosophy of Science from Hebrew University of Jerusalem and Ph.D. in BioMathematics (1980) from University of Washington in Seattle. His Post Doctorate studies were at University of Houston, Department of Mechanical Engineering. He participated in numerous wet and dry granulation and tableting projects in major pharmaceutical companies as a provider of process analytical instrumentation, conducted many seminars, performed numerous consulting services and wrote expert reports to clients in the pharmaceutical industry.
Author
Owner, Pharmaceutical Technology Consulting, Milev LLC, West Orange, NJ; General Manager, Measurement Control Corporation, East Hanover, NJ, USA
Content
1. Scale-Up Basics2. Dimensional Analysis, Principle of Similitude, Dimensionless Numbers, Comparison of attainable Froude Numbers3. Scientific scale-up procedure4. Case Studies5. Practical Considerations for End-Point Scale-Up6. List of Symbols and Dimensions, Literature Reference