Contributions to Nephrology / Cell Volume Regulation
1st Edition
Published on 14. September 1998
Book
Hardback
264 pages
978-3-8055-6737-4 (ISBN)
Description
This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few.
Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
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Content
Introduction to cell volume regulatory mechanisms; cell volume-regulated cation channels; cell volume-sensitive chloride channels; mechanisms of osmolyte release; sensors and signal transduction in the activation of cell volume regulatory ion transport systems; activation of protein kinases upon volume changes - role in cellular homoeostatsis; intracellular signalling in response to osmotic stress; approaches to identifying cell volume-regulated genes; the cytoskeleton in cell volume regulation; cell volume regulatory ion transport in cell migration; cell volume in cell proliferation and apoptotic cell death; cellular osmoregulation in kidney medulla; osmoregulation of liver cell function - signalling, osmolytes and cell heterogeneity; volume regulation and "cross-talk" in sodium-absorbing epithelial cells; pathophysiology of abnormal cell volume in human red cells; swelling-activated release of excitatory amino acids in the brain - relevance for pathophysiology.