Introduction to Mathematical Immunobiology of Cancer

In this book, actual problems of immune cells interaction with tumours are discussed in terms of the biological kinetics, theoretical biophysics, nonlinear systems and pattern recognition principles. On the basis of the detailed analysis of experimental and clinical data, mathematical models of tumour cells immune recognition mechanisms, co-operative phenomena, immune response dynamics in the whole are described and investigated. Modern mathematical methods are involved in the analysis of the models. Attention is paid to the determination of temporal and quantitative parameters of the ligand-receptor interactions, the processes of tumour cells interaction with different classes of immune cells and monoclonal antibodies.