Genomics and Health in the Developing World

Contributors ; Part I: Genomics in Medicine and Health-General ; 1. Genes and Genomes in Health and Disease: An Introduction ; Dhavendra Kumar ; 2. The Human Variome Project and the Developing World ; Richard G.H. Cotton ; 3. Human Genomic Variation Initiatives in Emerging Economies and Developing Countries ; Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar ; 4. The Genomic Map of Population Diversity in Asia ; Dhavendra Kumar ; 5. Ancestry, Disease and Variable Drug Response in the Genomic Era ; Charles Rotimi and Lynn Jorde ; 6. The Next Steps for Genomic Medicine: Challenges and Opportunities for the Developing World ; Billie-Jo Hardy, Beatrice Seguin, Federico Goodsaid, Gerardo Jimenez-Sanchez, Peter A. Singer, and Abdallah S. Daar ; 7. Consumer Perspectives on Genomics and Healthcare ; Alastair Kent ; 8. Transcultural Perspectives on Genetics and Genomics ; Dhavendra Kumar ; 9. Medical Genetics and Genomics Research in the Muslim World ; Aida I. Al-Aqeel ; 10. The Progress of Genomics in the Developing World: Rising Social, Economic, and Ethical Concerns ; Minakshi Bhardwaj ; 11. Genetic Outcomes of Consanguineous Marriages ; Alan H. Bittles and Michael L. Black ; 12. Autosomal Recessive Conditions and Autozygosity Mapping ; Colin A. Johnson and Eamonn R. Maher ; 13. Genetic Contribution to Malaria Susceptibility and Resistance ; Susana G. Campino and Taane G. Clark ; 14. Glucose 6-Phosphate Dehydrogenase Deficiency: Genetics, Pharmacogenetics, and Malaria Selection ; Lucio Luzzatto ; 15. Infections, Genomics, and Global Public Health ; Tikki Pang ; 16. Microbial Genomics and Global Health ; Rino Rappuoli ; 17. Pharmacogenetics and Pharmacogenomics in the Developing World ; Warren E. Hochfeld, Sahle M. Asfaha, Marco Alessandrini, Tyren M. Dodgen, Renier Myburgh, Arinda Eloff, and Michael S. Pepper ; 18. Nutrigenomic Research in World Populations ; Jim Kaput ; 19. Transgenic Foods and Nutritional Health in Developing Countries ; Dhavendra Kumar and Joel Cohen ; 20. The Burden of Inherited Disease in the Developing World: The Example of Inherited Blood Diseases ; David J. Weatherall ; 21. Health Implications of Inherited Disorders of Iron Overload ; Chun Yo Lok, Alison T. Merryweather-Clarke, and Kathryn J.H. Robson ; 22. Inherited Factors in Diabetes Mellitus and Related Metabolic Disorders in the Developing World ; Dwaipayan Bharadwaj, Nikhil Tandon, and Anubha Mahajan ; 23. Global Health Implications of Genetic Studies of Obesity and Type 2 Diabetes ; Jessica Buxton, Julia El-Sayed Moustafa, Haya Al-Saud, and Alexandra Blakemore ; 24. Health Implications of Familial Hyperlipidemia ; Deepak Bhatnagar ; 25. Global Health Implications of Inherited Renal Diseases ; Wendy Jones and Anand Saggar ; 26. The Burden of Congenital Anomalies on Global Health ; Dhavendra Kumar ; 27. Inherited Eye Diseases in Developing Countries ; Tiziana Cogliati, James Friedman, Norimoto Gotoh, Neeraj Agarwal, and Anand Swaroop ; 28. Principles and Practice of Newborn Screening-The Lessons from the Developed World ; Rodney J. Pollitt ; 29. Diagnostic Laboratory Genetic Testing - Models for the Developing World ; Peter Lunt ; 30. Ethical Issues Arising in Medical Genetics in Developing Countries ; Angus Clarke ; 31. Genetic and Genomics Services in Emerging Economies of the Developing World ; Robert George Elles ; Part II: Genomics in Medicine and Health-Regional ; Africa ; 32. Anthropology and Population Heterogeneity in North Africa ; Rym Kefi ; 33. The Genetic Landscape of Sub-Saharan African Populations ; Himla Soodyall and Carina M. Schlebusch ; 34. Genetic Disorders in North African Populations ; Romdhane Lilia and Abdelhak Sonia ; 35. Genetic Neurological Diseases in Tunisia ; Neziha Gouider-Khouja and Ibtihel Rebai ; 36. Hemoglobinopathies in Africa ; Ambroise Wonkam and Amanda Krause ; 37. The Burden of Birth Defects and Genetic Disease in Sub-Saharan Africa ; Ambroise Wonkam ; 38. Genetic Epidemiology of South Atlantic Oceanic Islands ; Peter Beighton ; 39. Genetic Disorders in Minority Groups in South Africa ; Peter Beighton ; 40. Hereditary Deafness in Southern Africa ; Peter Beighton and Sean Sellars ; 41. Heritable Disorders of the Skeleton in South Africa ; Peter Beighton ; 42. Heritable Disorders of Connective Tissue in South Africa ; Peter Beighton ; 43. Genetic Perspectives of Tuberculosis in Southern Africa ; Erika de Wit, Marlo Moller, and Eileen Hoal ; 44. Familial Cancer Syndromes in Africa ; Yonglan Zheng, Toshio F. Yoshimatsu, and Olufunmilayo I. Olopade ; 45. Genetic Counseling in South Africa ; Jacquie Greenberg, Jennifer Kromberg, Kelly Loggenberg, and Tina-Marie Wessels ; 46. Prenatal Diagnostic Services and Prevention of Birth Defects in South Africa ; Michael Urban and Lut Geerts ; 47. Sociocultural Perspectives of Inherited Diseases in Southern Africa ; Claire Penn and Jennifer Watermeyer ; 48. Ethical, Legal, and SocioCultural Issues and Genetic Services in Southern Africa ; Jennifer G.R. Kromberg and Trefor Jenkins ; 49. The Genomic Research and Health Applications in South Africa ; Billie-Jo Hardy, Beatrice Seguin, Raj Ramesar, Peter A. Singer and Abdallah S. Daar ; Arab and Middle East ; 50. Hereditary Disorders in Arabs ; Ghazi Omar Tadmouri and Mahmoud Taleb Al Ali ; 51. Community Health Implications of Consanguinity in Arab Populations ; Ghazi O. Tadmouri, Pratibha Nair, Tasneem Obeid, and Hanan Hamamy ; 52. Clinical Dysmorphology in the Arab World ; Lihadh Al-Gazali and Hanan Hamamy ; 53. The Population Genetics and Hereditary Diseases of Bahrain ; Shaikha Salim Al-Arrayed ; 54. Genetic Diseases in the Sultanate of Oman ; Anna Rajab and Michael A.Patton ; 55. Genetic Disorders in Lebanon: Challenges and Opportunities ; Issam I. Khneisser, Salim. M. Adib, and Andre Megarbane ; 56. Genetic Disease in Palestine and Palestinians ; Bassam Abu-Libdeh, Peter D. Turnpenny, and Ahmed Teebi ; 57. Genetic Skin Diseases in the Arab World ; Mourad Mokni, Cherine Charfeddine, and Sonia Abdelhak ; 58. Hereditary Diseases of the Nervous System in Arabs ; Nisrine Bissar-Tadmouri, Mohamad Al-Homssi, and Pratiba Nair ; 59. Preimplantation Genetic Diagnosis in Saudi Arabia ; Serdar Coskun, Wafa Qubbaj, and Aida I. Al-Aqeel ; Asia-Pacific ; 60. Genomics for Universal Healthcare in Thailand ; Beatrice Seguin, Billie-Jo Hardy, Peter A. Singer, and Abdallah S. Daar ; 61. Screening Newborns in the Asia-Pacific Region ; Carmencita D. Padilla and Bradford L. Therrell ; 62. Clinical Dysmorphology and Birth Defects Registry in the Asia-Pacific Region ; Meow Keong Thong ; 63. Prevention and Control of Thalassemia in Thailand ; Chanane Wanapirak, Jintana Pattanapongthorn, Pranee Winichagoon, and Suthat Fucharoen ; 64. Inherited Metabolic Disorders in Thailand and the Asia-Pacific ; Pornswan Wasant ; 65. Genetic Skeletal Dysplasias in Thailand ; Pornswan Wasant ; 66. Medical Genetic Services in the Philippines ; Carmencita Padilla, Eva Maria Cutiongco-de la Paz, and Catherine Lynn Silao ; Chinese Subcontinent ; 67. Community and Public Health Genetics in China ; Manshu Song, Youxin Wang, Lijuan Wu, Yun Wang, and Wei Wang ; 68. Genetic Epidemiology in China ; Peng-Gao Li, Yan He and Wei Wang ; 69. Traditional Chinese Medicine in the Area of Genomics ; Hong-Min Yun, Manshu Song, and Wei Wang ; 70. Inherited Factors in Cardiovascular Disease in China ; Ling Zhang Ying Dai, and Wei Wang ; 71. Familial and Genetic Cancer in China ; Fen Liu and Wei Wang ; 72. Genomic Medicine in Taiwan: Research and Developments ; Ming Ta Michael Lee, Chien-Hsiun Chen, and Yuan-Tsong Chen ; Indian Subcontinent ; 73. The Indian Subcontinent and its People ; Dhavendra Kumar ; 74. Genomic Perspectives of Peopling and Languages of the Indian Subcontinent ; Ganesh Prasad Arunkumar, Varatharajan Santhakumari Arun, Adhikarla Syama, Valampuri John Mary Selvam Kavitha, and Ramasamy M. Pitchappan ; 75. Genomic Diversity of HLA in the Indian Subcontinent ; Narinder K. Mehra and Gurvinder Kaur ; 76. Genomic Applications in Medicine and Health in India ; Billie-Jo Hardy, Beatrice Seguin, Peter A. Singer, Mitali Mukerji, Samir K. Brahmachari and Abdallah S. Daar ; 77. Epidemiology of Genetic Diseases in the Indian Subcontinent ; Ishwar C. Verma and Dhavendra Kumar ; 78. Genetic Services in India: A Model for Developing Countries ; Ratna D. Puri and Ishwar C. Verma ; 79. The Practice of Genetic Counseling in India ; Meenakshi Bhatt ; 80. Social and Cultural Aspects of Customary Consanguineous Marriages in South Asia ; Rafat Hussain ; 81. Medical Genetics and Genomics in Sri Lanka ; Vajira H.W. Dissanayake ; 82. Inherited Factors in Obstructive Lung Diseases in India ; Amrendra Kumar Gupta, Balaram Ghosh, and Anurag Agrawal ; 83. Inherited Metabolic Disease in India ; Bal N. Apte ; 84. Genetic Variation and Genetic Epidemiology of Sri Lanka ; Deepthi C. de Silva ; 85. Familial Cancer and Cancer Genetics in the Indian Subcontinent ; Dhavendra Kumar ; 86. Inherited Disorders of the Eye in the Indian Subcontinent ; Govindasamy Kumaramanickavel ; 87. Type 2 Diabetes Mellitus in India ; Radha Venkatesan, Kanthimathi Sekar and Viswanathan Mohan ; 88. Hereditary Spinocerebellar Ataxias in India ; Mohammed Faruq, Uma Mittal, Achal K. Srivastava, and Mitali Mukerji ; 89. Malformation Syndromes in India ; Shubha Phadke ; 90. Thalassemias and Abnormal Hemoglobins of the Indian Subcontinent ; John Old ; 91. The Management of Inherited Blood Diseases in the Indian Subcontinent ; Reena Das ; 92. Conventional and Molecular Cytogenetics in India ; Prochi F. Madon ; 93. Genetic Studies of Parkinson's Disease in India ; Jharna Ray ; 94. The Genetic Basis of Alcoholism in India ; Meera Vasani ; 95. The Genetics of Autism in India ; G.K. Chetan, K.R. Manjunatha, Sam Balu, H.N. Venkatesh, and S.C. Grimaji ; 96. The Genetics of Leprosy in India ; Mariakuttikan Jayalakshmi, Narayanan Kalyanaraman, and Ramasamy Pitchappan ; 97. The Current Status of Medical Genetics in India ; Neerja Gupta and Madhulika Kabra ; 98. The Indian Landscape of Human/Medical Genetics Research and Service ; Swati Naik, Arvind Rup Singh, and Jai Rup Singh ; Latin America and the Caribbean ; 99. Design and Implementation of a Platform for Genomic Medicine in Mexico ; Gerardo Jimenez-Sanchez, Julio Frenk, and Guillermo Soberon ; 100. Anthropological and Medical Implications of Genetic Admixture in the Mexican Mestizo Population ; Ricardo M. Cerda-Flores and Augusto Rojas-Martinez ; 101. Medical and Human Genetics in Ecuador ; Cesar Paz-y-Mino ; 102. The Brazilian Ancestrome ; Sergio D.J. Pena ; 103. The Practice of Medical Genetics in Brazil ; Dafne Dain Gandelman Horovitz, Antonia Paula Marques-de-Faria, and Victor Evangelista de Faria Ferraz ; 104. Population Medical Genetics in Brazil ; Lavinia Schuller-Faccini and Roberto Giugliani ; 105. Medical Genetic Services in Latin America: Focus in Argentina ; Victor B. Penchaszadeh ; 106. Hereditary Ataxias in Cuba ; Luis Velazquez-Perez, Jose Miguel Laffita-Mesa, and Roberto Rodriguez-Labrada ; 107. Latin American School of Human and Medical Genetics and Latin American Network of Human Genetics: promoting education, interaction and networking across Latin America ; Roberto Giugliani, Guilherme Baldo, and Ursula Matte ; Russia, Central Asia, and Europe ; 108. Genetic Legacy of Populations in Eurasia ; I.A. Kutuev, B.B. Yunusbayev, and E.K. Khusnutdinova ; 109. MtDNA and Y-chromosomal Variation in Populations of Sakha (Yakutia) ; Sardana A. Fedorova, Elza K. Khusnutdinova, and Richard Villems ; 110. Epidemiology of Hereditary Diseases in the European Sector of Russia ; E.K. Ginter and R.A. Zinchenko ; 111. Hereditary Diseases among the Yakuts ; Nadezda R. Maksimova and Anna N. Nogovitsina ; 112. Hereditary Diseases in Siberian Populations ; Ludmila P. Nazarenko and V.P. Puzyrev ; 113. Hereditary Diseases in the Volga-Ural Region of Russia ; Irina M. Khidiyatova, Irina R. Gilyazova, Vita L. Akhmetova and Elza K. Khusnutdinova ; 114. Inherited Neuropsychiatric Disorders in Russia ; D. Gaysina, A. Zainullina, and E. Khusnutdinova ; 115. Genetic and Genomic Perspectives of Medical and Health Education in Hungary ; Bela Melegh ; 116. Human and Medical Genetics in Hungary ; Bela Melegh ; 117. The Genetics of Alcohol Dependence in Russia ; A. Kazantseva, G. Faskhutdinova, and E. Khusnutdinova ; 118. Medical Genetics Teaching and Training in Russia ; S.I. Kozlova and E.K. Ginter ; 119. Ethical and Legal Aspects of Medical Genetics in Russia ; V.L. Izhevskaya and V.I. Ivanov ; 120. Bioethical Aspects of Genetics and Genomics in Yakut (Siberia) ; S.K. Kononova, S.A. Fedorova, and E. Khusnutdinova ; 121. Inherited Metabolic Diseases among Migrant Ethnic Populations in the United Kingdom ; Anupam Chakrapani and Maureen Cleary ; 122. Views of Inherited illness among British Pakistani Users of Genetic Services ; Alison Shaw and Jane Hurst ; 123. Social, Cultural, and Religious Issues Related to Genetic Diseases among the Bangladeshis in the UK ; Santi Rozario and Sophie Gilliat-Ray