Frontiers in Cardiovascular Biology
Description
This book presents an integrated view of molecular, cellular, and translational aspects of cardiovascular research. It emphasizes emerging biomarkers, RNA-based therapies, extracellular vesicles, omics platforms, and artificial intelligence in risk prediction and precision medicine.
The book is an ideal resource for undergraduate and graduate students, PhD researchers, biomedical scientists, and clinicians interested in cardiovascular biology and translational medicine.
The book aims to bridge basic research with clinical applications in cardiovascular disease (CVD), the leading cause of global mortality. Serving as both a teaching resource and reference, this volume provides a clear, up-to-date guide to current trends, challenges, and innovations shaping cardiovascular science.
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Persons
Dr. Gaurav Kumar is a researcher in the field of cardiometabolic biology, with a focus on understanding the molecular mechanisms that govern cardiac function and metabolic regulation. His work centers on the identification and characterization of post-translational modifications associated with novel metabolites in cardiomyocytes, aiming to uncover how these biochemical alterations influence cellular signaling, energy homeostasis, and disease progression.
By integrating advanced molecular biology, biochemical approaches, and cellular models, Dr. Kumar's research seeks to bridge the gap between metabolism and cardiac physiology. His studies provide insights into how dynamic modifications of proteins and metabolites contribute to the pathogenesis of cardiometabolic disorders, including hypertension, heart failure, and metabolic syndrome. Through this work, he aims to identify new therapeutic targets and strategies for the treatment of cardiovascular diseases with metabolic underpinnings.
Dr. Kumar's contributions are positioned at the intersection of metabolism, signaling, and cardiovascular research, reflecting a growing emphasis on systems-level understanding of disease mechanisms in modern biomedical science.
Sonam Mittal is a researcher specializing in breast cancer biology, with a strong focus on the discovery and validation of biomarkers for improved diagnosis and prognosis. Her work aims to unravel the molecular and cellular heterogeneity of breast cancer, enabling more precise stratification of patients and the development of personalized therapeutic approaches.
Content
Introduction to Cardiovascular Diseases: Global Burden, Mechanisms, and Challenges.- Cardiovascular Cell Biology: Endothelial Cells, Smooth Muscle, and Cardiomyocytes.- Inflammation, Oxidative Stress, and Immune Signaling in CVD.- MicroRNAs in Cardiovascular Health and Disease: From Regulation to Therapy.- Extracellular Vesicles as Mediators and Biomarkers in Cardiovascular Disorders.- Protein Biomarkers and Novel Therapeutic Targets in Cardiovascular Pathology.- Advances in RNA-Based Therapies and Gene Editing for Cardiovascular Treatment.- Organoids, iPSCs, and In Vitro Models for Cardiovascular Disease Research.- Omics Approaches in Cardiovascular Science: Genomics, Proteomics, and Metabolomics.- Artificial Intelligence and Machine Learning in Cardiovascular Risk Prediction.- Translational Challenges: Bridging Bench Research with Clinical Practice.- Future Perspectives in Cardiovascular Therapeutics and Precision Medicine.