Biochemistry of Signal Transduction

Regulation of gene expression; regulation of enzyme activities, function and structure of signalling pathways, signal transduction through nuclear receptors, g-protein-coupled signal transduction pathways; intracellular signalling agents: "second messenger"; ser/thr-specific protein kinases and protein phosphatases; signal transduction through transmembrane receptors with tyrosine-specific protein kinase activity; signal transduction through ras-proteins; intracellular signal transduction: protein kinase cascade of MAP-kinase pathways; membrane receptors with associated tyrosine-kinase activity; transmembrane receptors with intrinsic ser/thr-kinase activity and signal transduction in the "two-component pathway"; integral construction, networks, and specifity of signalling pathways; regulation of the cell cycle; malfunction of signalling pathways and tumor formation: oncogenes and tumor suppressants; apoptosis; ion channels and signal transduction.