The Extracellular Matrix and the Tumor Microenvironment
Description
This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.
Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression.
Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors.
The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM.
The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
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Persons
Ilona Kovalszky. MD, PhD, DSc. Semmelweis University Faculty of Medicine, Department of Pathology & Experimental Cancer Research, Budapest, Hungary. Professor emeritus of pathology. Previous leader of Pathology Doctoral School. She is board certified from pathology, internal medicine and diagnostic molecular pathology. Chief of Laboratory of Molecular Pathology. Research: Study the implication of tumor-stroma interactions related to progression of cancer. Her major interests are the regulatory mechanisms modified by proteoglycans in normal and tumor tissues. Introduction of recombinant gene technology for detection of proteoglycans participating in the process of cancer formation and metastasis. Molecular mechanism of liver fibrogenesis and carcinogenesis and molecular diagnosis for early detection of cancer.
Marco Franchi. PhD. Head of the course of Human Anatomy (C.I.)-Anatomy of the Locomotor Apparatus in the Faculty of Motor Sciences, University of Bologna, Bologna and Rimini. Teaching in the course on Human Anatomy in the Postgraduate School of Sport Medicine, Faculty of Medicine, University of Bologna. Research Assistant in the Faculty of Motor Sciences, University of Bologna. Research: study of the ultrastructure of collagen, the elastic system and proteoglycans; the study of the interaction between collagen and proteoglycans in fibrous connective tissues. Dr Franchi supervises investigations on the morphological and functional collagen arrangement of extracellular matrix in 3D cultures and the influence of different extracellular matrix molecules (glycosaminoglycans) on the phenotype and behavior and breast cancer cells.
Laura D. Alaniz. PhD. Independent researcher from CONICET. Adjunct Professor of Biological Chemistry and Immunology and Immunogenetics, ECANA, UNNOBA. Head of the Laboratory of Tumor Microenvironment in CIBA, CITNOBA. Research: Study the tumor microenvironment particularly extracellular matrix (ECM) as a modulator of the immunological behavior of different types of cancer. Besides, Dr Alaniz L directs studies of tumor resistance mechanisms associated with alterations of the ECM. Specifically, the laboratory focuses on the study of the glycosaminoglycan: Hyaluronic Acid and its metabolism in the context of solid tumors and tissue regeneration.
Content
Table of Contents
Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation.
Dragana Nikitovits, George Tzanakakis
The role of decorin in cancer
Kornélia Baghy, Andrea Reszegi, Zsolt Horváth, Ilona Kovalszky
The mystery of syndecan-1 in tumor development and progression
Ilona Kovalszky, Kornélia Baghy, Andrea Reszegi, Péter Hollósi, Anders Hjerpe, Katalin Dobra
Syndecan-2 Biology and its Role in Colorectal CarcinomaEok-Soo Oh and John R. Couchman
Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy
Athanasios Papadas, Alexander Cicala, Sean G. Kraus, Garrett Arauz, Gauri Deb, Dustin Deming, and Fotis AsimakopoulosCirculating proteoglycans/glycosaminoglycans as cancer biomarkers
Antonio Junior Lepedda, Gabriele Nieddu, Nikos Karamanos, Marilena Formato
Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects"
Antonella Icardi, Silvina L Lompardia, Daniela L. Papademetrio, Paolo Rosales, Mariángeles Díaz, Matías A. Pibuel Laura Alaniz, Elida Alvarez.Heparanase: a paramount enzyme for cancer initiation, progression and metastasis
Valentina Masola, Nicola Greco, Giovanni Gambaro, Marco Franchi and Maurizio Onisto
Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved
Patricia Rousselle and Konrad Beck
Basement membrane, collagen, and fibronectin: physical interactions with cancer cells.
Franchi Marco, Valentina Masola, Konstantinos-Athanasios Karamanos, Leonardo Franchi, Konstantina Kyriakopoulou, Maurizio Onisto, Concettina Cappadone.
Integrins in cancer: re-focusing on the tumor microenvironment
Cédric Zeltz, Ning Lu, Ritva Heljasvaara and Donald Gullberg
Adipose compounds in breast tumor extracellular matrix
Flavia Piccioni, and Paola De Luca.
Extracellular matrix as a metabolic niche in cancer
Anna Sebestyén, Titanilla Dankó, Dániel Sztankovics, Dorottya Moldvai, Ildikó Krencz, Regina Raffay and Gábor Petovári
The role of inflammatory cells in tumor angiogenesis
Roberto Tamma, Tiziana Annese, Domenico Ribatti
Cancer angiogenesis and its master regulator perlecan
Ilona Kovalszky, Loránd Váncza, Péter Tátrai, Kornélia Baghy
The microRNA-extracellular matrix interplay in breast cancer
Zoi Piperigkou, Dimitra Manou, Dimitra Bainantzou, Vasiliki Zolota
?fthymia Papakonstantinou4, Achilleas D. Theocharis1, Nikos K. Karamanos
The impact of the extracellular matrix on immunotherapy success
Manglio M Rizzo, Mariel A Fusco and Mariana Malvicini
Exploiting hyaluronan-CD44 network in tumor therapy
Theodoros T. Karalis, Spyros S. Skandalis