Genetic Screening
From Newborns to D.N.A. Typing - International Workshop Proceedings
Published in April 1990
Book
Hardback
418 pages
978-0-444-81203-2 (ISBN)
Description
Dramatic advances in recombinant DNA technology are about to bring fundamental changes in genetic screening. As clinically oriented researchers pursue dozens of disease genes, basic scientists dazzle us with new technologies, one of the most important being the polymerase chain reaction. The questions accompanying screening scenarios seem to amplify at a rate approaching that of the polymerase chain reaction. Genetic Screening: From Newborns to DNA Typing arrives at a crucial moment to help us confront these and many other questions. It is the work product of two dozen leading authorities in the field of newborn screening who gathered to focus their thoughts intensively on the present state of screening and to formulate principles to guide the practice of neonatal screening in the next decade. The book is logically organized and presents much valuable material, examines the more recent experiences in screening for congenital diseases, ascertaining HIV seroprevalence, and raises important ethical and legal questions. The volume is an admirable conception and will undoubtedly be of interest to all involved with genetic testing.
Dramatic advances in recombinant DNA technology are about to bring fundamental changes in genetic screening. As clinically oriented researchers pursue dozens of disease genes, basic scientists dazzle us with new technologies, one of the most important being the polymerase chain reaction. The questions accompanying screening scenarios seem to amplify at a rate approaching that of the polymerase chain reaction. Genetic Screening: From Newborns to DNA Typing arrives at a crucial moment to help us confront these and many other questions. It is the work product of two dozen leading authorities in the field of newborn screening who gathered to focus their thoughts intensively on the present state of screening and to formulate principles to guide the practice of neonatal screening in the next decade. The book is logically organized and presents much valuable material, examines the more recent experiences in screening for congenital diseases, ascertaining HIV seroprevalence, and raises important ethical and legal questions. The volume is an admirable conception and will undoubtedly be of interest to all involved with genetic testing.
Dramatic advances in recombinant DNA technology are about to bring fundamental changes in genetic screening. As clinically oriented researchers pursue dozens of disease genes, basic scientists dazzle us with new technologies, one of the most important being the polymerase chain reaction. The questions accompanying screening scenarios seem to amplify at a rate approaching that of the polymerase chain reaction. Genetic Screening: From Newborns to DNA Typing arrives at a crucial moment to help us confront these and many other questions. It is the work product of two dozen leading authorities in the field of newborn screening who gathered to focus their thoughts intensively on the present state of screening and to formulate principles to guide the practice of neonatal screening in the next decade. The book is logically organized and presents much valuable material, examines the more recent experiences in screening for congenital diseases, ascertaining HIV seroprevalence, and raises important ethical and legal questions. The volume is an admirable conception and will undoubtedly be of interest to all involved with genetic testing.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 230 mm
Weight
960 gr
ISBN-13
978-0-444-81203-2 (9780444812032)
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Schweitzer Classification
Content
Opening address (C.M. Laberge). List of participants. Session I : Classical Screening: An Update . Neonatal Genetic Screening . Update of the 1984 Chicago meeting on quality assurance in screening (R.P. Hormuth). To screen or not to screen for congenital adrenal hyperplasia: Is that the question? (M.L. Mitchell et al.). 15 years of screening for congenital hypothyroidism: The remaining controversies (J.H. Dussault). The Lyon experience in neonatal screening for muscular dystrophy: The attenuation of critics (J.M. Robert et al.). Ethical implications in diagnosis and treatment of non-disease (DIS - ) phenotypes issuing from screening programs (S.B. Melancon). The French program of systematic neonatal screening. I: Organization and results. II: Development and the future. (J. Frezal et al.). Session II: Classical Screening: An Update. Neonatal Surveillance Screening . Use of blood spots for epidemiological studies: Toxoplasmosis and HIV (R. Hoff and B. Weiblen). Newborn screening and surveillance for infectious diseases: Anticipation of treatment options and impact on minority groups (G.F. Grady). Dilemmas in obstetric and neonatal HIV screening: A pediatric and epidemiologic point of view (A. Willoughby). Research or surveillance: Anonymous seroprevalence studies - ethical and epidemiological considerations in public health planning (C. Hankins). Anonymous HIV seroprevalence studies: Ethic conditions (D. Roy). Highlights and discussion of Session I and II: Classical screening, An Update . Whether classical or radical, the problem is the same (C.R. Scriver). I. Neonatal Genetic Screening. II. Neonatal Surveillance Screening. Submitted papers for Session III: Future Types of Screening: A Prospectus. DNA Analysis. Automated DNA screening: the problems and the possibilities (M. Leppert and K. Ward). PCR and its application to detection of genetic and infectious disorders in infants and children (A. Comeau and R. Hoff). RFLP haplotype analysis and PCR amplification of dried blood spots in phenylketonuria: Ethnics and ethics (J. Rey et al.). Carrier screening for Tay-Sachs disease: Prospects for direct mutation analysis (J.T.R. Clarke et al.). Does research success in Duchenne-Becker muscular dystrophy now warrant neonatal mass screening? The perspective of a molecular biologist (R.G. Worton). Submitted papers for Session IV: Future Types of Screening: A Prospectus . Ethical and Legal Safeguards . Balancing the individual's rights to privacy against the need for information to protect and advance public health (G.C. Cunningham). DNA testing, banking and individual rights (L.B. Andrews). International perspectives on voluntary versus mandatory screening and third party access to tests results (D.C. Wertz and J.C. Fletcher). Genetic heritage: The international debate (B.M. Knoppers). Opportunity and danger: Medical, ethical and social implications of early DNA screening for identification of genetic risk of common adult onset disorders (P.A. Baird).