Meera Khan, P dedication issue
"Cytogenetics and Cell Genetics", Vol. 86, No. 2. Special Topic Issue: Cytogenetics and Cell Genetics 1999, Vol. 86, No. 2
Published on 14. October 1999
Book
Paperback/Softback
78 pages
978-3-8055-6989-7 (ISBN)
Description
This special issue of Cytogenetics and Cell Genetics is dedicated to Prof. Dr. P. Meera Khan who died on April 1, 1998. Edited by Drs. Peter Pearson (Utrecht, The Netherlands) and Harold P. Klinger (New York), it contains 14 papers by friends and colleagues of Dr. Khan. Dr. Khan's career spanned many aspects of human genetics, including somatic cell genetics, gene mapping, isoenzyme studies, gene nomenclature and, during the last 15 years, the study of familial colon cancer. Shortly following his death, an international symposium over the impact of molecular genetics on the clinical treatment of colon cancer was held in Leiden. This symposium had originally been scheduled as a farewell for Dr. Khan's retirement, long before it was realised that Dr. Khan was terminally ill. It is fitting that this memorial issue largely comprises articles based on presentations made at the symposium plus others submitted by close friends and colleagues that characterize areas of research in which Dr. Khan was involved.
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Content
Colon polyps - a damaged developmental system and a precursor to cancer, R.L. White; familial adenomatous polyposis (FAP) and its gene, APC, W. Bodmer; mechanisms of APC-driven tumorigenesis -lessons from mouse models, R. Fodde, R. Smits et al; molecular pathology of colorectal cancer, F.T. Bosman; genetic predictive testing for bowel cancer predisposition - the impact on the individual, P.D. Chapman and J. Burn; familial adenomatous polyposis - from bedside to bench and vice versa, G. Griffioen, H.F.A. Vasen et al; hereditary nonpolyposis colorectal cancer (HNPCC), H.T. Lynch; clinical implications of genetic testing of hereditary nonpolyposis colorectal cancer, H.F.A. Vasen and J. Wijnen; commentary on the current role of human genetics in health care, G.J.B. Van Ommen; genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer, T.K. Weber, J. Conroy et al; population genomics in Sardinia - a novel approach to hunt for genomic combinations underlying complex traits and diseases, M. Siniscalco, R. Robledo et al; leber hereditary optic neuropathy (LHON) - a mitochondrial disease with unresolved complexities, L.N. Went; comparative genomic hybridization analysis of hepatoblastomas -additional evidence for a genetic link with Wilms tumour and rhabdomyosarcoma, M. Steenman, G. Tomlinson et al; the changing challenges of nomenclature, H. Wain, J. White and S. Povey.