Fetal Therapy

Preface; Foreword; Part I. General Principles: 1. The rationale for fetal therapy; 2. Insights into pathogenesis of adult cardiovascular disease from fetal animal studies; 3. Human embryology: molecular mechanisms of embryonic disease; 4. Ethics of fetal therapy; 5. Fetal therapy choices: about risks, emotions, and the doctor's role in the decision making process; Part II. Fetal Disease: Pathogenesis and Principles: 6. Red cell alloimmunization: immunobiology, clinical disease, and management; 7. Fetal and neonatal alloimmune thrombocytopenia; 8.1. Fetal dysrhythmias: the effects of antiarrhythmic therapy on the immature heart; 8.2. Fetal dysrhythmias: clinical management; 9.1. Structural heart disease: embryology; 9.2. Structural heart disease: genetic influences; 9.3. Structural heart disease: fetal cardiac interventions; 10.1. Manipulation of amniotic fluid volume: homeostasis of fluid volumes in the amniotic cavity; 10.2. Manipulation of amniotic fluid volume: oligohydramnios and polyhydramnios; 11.1. Twin-to-twin transfusion syndrome: scientific basis; 11.2. Twin-to-twin transfusion syndrome: placental circulation; 11.3. Twin-to-twin transfusion syndrome: cardiovascular manifestations; 11.4. Twin-to-twin transfusion syndrome: treatment by fetoscopic laser ablation; 11.5. Twin-to-twin transfusion syndrome: management of stage I disease; 12.1. Twin reverse arterial perfusion (TRAP) sequence: pathophysiology; 12.2. Twin reverse arterial perfusion (TRAP) sequence: in-utero treatment; 13.1. Fetal infections: fetal immune responses to congenital infections; 13.2. Fetal infections: clinical management; 14.1. Fetal urinary tract obstruction: pathophysiology; 14.2. Fetal urinary tract obstruction: prenatal assessment and prognosis; 14.3. Fetal urinary tract obstruction: fetal cystoscopy; 14.4. Fetal urinary tract obstruction: in-utero intervention; 15.1. Fetal lung growth, development and lung fluid: physiology and pathophysiology; 15.2. Fetal lung growth, development, and lung fluid: clinical management of pleural effusion and pulmonary pathology; 16.1. Neural tube defects: pathophysiology and prevention; 16.2. Neural tube defects: clinical management; 17.1. Fetal tumors: pathophysiology; 17.2. Fetal tumors: clinical management; 18.1. Intrauterine growth restriction: placental basis and implications for clinical practice; 18.2. Intrauterine growth restriction: differential diagnosis and management; 19.1. Congenital diaphragmatic hernia: pathophysiology; 19.2. Congenital diaphragmatic hernia: clinical antenatal management; 20.1. Fetal stem cell transplantation: stem cell biology basics; 20.2. Fetal stem cell transplantation: clinical potential; 20.3. Fetal stem cell transplantation: fetal tissue engineering; 21. Gene therapy: physiological principles and clinical potential; 22. The future: fetal therapies and translation studies: global alignment, coordination and collaboration in perinatal research: The Global Obstetrics Network (GONet) initiative; Index.