New Opioid Receptor Modulators and Agonists
Relevance for Pain and Opioid Use Disorder Management
Published on 25. September 2025
Book
Paperback/Softback
238 pages
978-0-443-26504-4 (ISBN)
Description
New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides crucial insights for developing ideal synthetic opioids. It discusses opioid receptor modulators' structures and mechanisms, and their potential applications in treating pain, misuse, and addiction. This comprehensive resource delves into current research and therapeutic development avenues regarding opioid receptors' structure and function. Sections cover the rationale for developing allosteric modulators, identifying allosteric sites on opioid receptors, and the modulators' modes of action. Readers will gain a thorough understanding of creating ideal synthetic opioids and potential future research.
It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose.
It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose.
More details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
College/higher education
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 277 mm
Width: 211 mm
Thickness: 13 mm
Weight
699 gr
ISBN-13
978-0-443-26504-4 (9780443265044)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
MD Kaye | Scott Edwards
New Opioid Receptor Modulators and Agonists
Relevance for Pain and Opioid Use Disorder Management
E-Book
09/2025
Elsevier
€153.99
Available for download
Persons
Dr. Kaye has been a practicing physician scientist for over 30 years. He is Vice Chancellor of Academic Affairs at LSU Health Shreveport. It has been a personal goal of his to significantly contribute to the education and development of future physicians, scientists, professors, and researchers. Dr. Kaye's laboratory has made significant scientific contributions through in vivo, prospective human clinical trials, and retrospective data review research involving anesthesiology airway devices, multimodal pain management, and novel pharmaceuticals. In 2022 he has contributed to 12 books, 44 book chapters, and 144 PubMed articles, all of which include students, residents, and faculty, and involve collaborations from different departments at LSU. Overall, he has published over 1000 PubMed articles and has authored/co-authored over 300 abstracts. Dr. Kaye has mentored hundreds of clinical fellows, residents, and faculty appointments, in addition to hundreds of medical and graduate students. Dr. Edwards received his PhD in the Departments of Neuroscience and Psychiatry at the University of Texas Southwestern Medical Center with support from the National Institute on Drug Abuse (NIDA). Afterwards, he joined the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute where he was awarded a K99/R00 Pathway to Independence award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Dr. Edwards joined the Department of Physiology at LSU Health New Orleans in 2013 and is a member of the NIAAA-funded P60 Comprehensive Alcohol-HIV/AIDS Research Center and Alcohol & Drug Abuse Center of Excellence. His preclinical and translational research examines neurobiological interactions between chronic pain and substance use disorders.
Content
The Opioid Receptor System and Novel Aspects of Opioid Pharmacology
1. Making Sense of the Complexities of Opioid Receptor Function: Evolving Appreciation of Opioid Receptor Classification and Basic Characteristics
2. Allostery at Opioid Receptors: Modulation with Small Molecule Ligands, Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management
3. Opioid Agonist and Antagonist Pharmacology: Phenylpiperidines, Tramadol, Buprenoprhine, Methadone, and Codeine Derivatives Synthetic Opioid Clinical Considerations
4. Pharmacogenomics/Precision Medicine: Opioid-related Interactions and Metabolism Considerations
5. Opioid-associated Syndromes and Comorbidities
6. Opioid-induced Hyperalgesia
7. Drug Facts: Novel Synthetic Opioids Synthetic Opioid Misuse and Pain Management
8. Roots of the Opioid Crisis: Description of the Four Waves of the Opioid Epidemic
9. Opioids and Risk of Dependency: Neurobiology of Opioid Use Disorder
10. Opioids and Risk of Dependency: Responsibilities of Healthcare Workers, Manufacturers, and Pharmacists
11. CDC Guidelines for Chronic Pain in the Adult, Including Newer Guidelines Against Co-prescription with Benzodiazepines.
12. Commonly Prescribed Opioids and Adjuvants in Acute and Chronic Pain Management
13. Clinical Considerations of Commonly Prescribed Medications in Substance Abuse Management (e.g., buprenorphine (how is it prescribed); methadone (concerns over prolonged QT EKG prior to administration; urine drug screens
14. The Role of Naltrexone and Novel Preparations for Substance Abuse and Pain Management
15. Palliative Care for Cancer and Considerations for Opioid-mediated Suppression of Natural Killer Cells
16. Abuse Deterrent Formulations of Opioids and Opioid Vaccines
17. Opioid Detoxification Techniques
1. Making Sense of the Complexities of Opioid Receptor Function: Evolving Appreciation of Opioid Receptor Classification and Basic Characteristics
2. Allostery at Opioid Receptors: Modulation with Small Molecule Ligands, Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management
3. Opioid Agonist and Antagonist Pharmacology: Phenylpiperidines, Tramadol, Buprenoprhine, Methadone, and Codeine Derivatives Synthetic Opioid Clinical Considerations
4. Pharmacogenomics/Precision Medicine: Opioid-related Interactions and Metabolism Considerations
5. Opioid-associated Syndromes and Comorbidities
6. Opioid-induced Hyperalgesia
7. Drug Facts: Novel Synthetic Opioids Synthetic Opioid Misuse and Pain Management
8. Roots of the Opioid Crisis: Description of the Four Waves of the Opioid Epidemic
9. Opioids and Risk of Dependency: Neurobiology of Opioid Use Disorder
10. Opioids and Risk of Dependency: Responsibilities of Healthcare Workers, Manufacturers, and Pharmacists
11. CDC Guidelines for Chronic Pain in the Adult, Including Newer Guidelines Against Co-prescription with Benzodiazepines.
12. Commonly Prescribed Opioids and Adjuvants in Acute and Chronic Pain Management
13. Clinical Considerations of Commonly Prescribed Medications in Substance Abuse Management (e.g., buprenorphine (how is it prescribed); methadone (concerns over prolonged QT EKG prior to administration; urine drug screens
14. The Role of Naltrexone and Novel Preparations for Substance Abuse and Pain Management
15. Palliative Care for Cancer and Considerations for Opioid-mediated Suppression of Natural Killer Cells
16. Abuse Deterrent Formulations of Opioids and Opioid Vaccines
17. Opioid Detoxification Techniques