K.T.
Relationships between Structure and Function of Cytochrome P-450. Experiments, Calculations, Models
Akademie Verlag Berlin
Published on 15. November 1992
Book
Hardback
380 pages
978-3-05-501329-4 (ISBN)
Description
A challenging task for bioscientists has always been and still is the question of how a distinct enzymatic function is encoded in a corresponding molecular structure. Genetic engineering techniques, computer aided calculations and sophisticated experimental techniques nowadays provide facilities to make a deeper understanding of structure-function relationships a realistic aim. Volume Seven of this series comprehends data which represent seminal developments in this field. The contributions cover a broad scope ranging from 3rd-structure studies of engineered protein molecules to understand the functional importance of distinct amino acids, calculations of the active site specificities with respect to reaction mechanisms and prediciton of membrane topology supported by experimental data. Internationally acknowledged experts present in 10 articles an updated view of structure-function relationships of the key enzyme in biotransformation.
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Persons
Content
X-Ray crystallographic structural studies of cytochrome P-450 cam - factors controlling substrate metabolism, R. Raag and T.L. Poulos; topology of membrane-bound cytochrome P-450-prediction and evidence, H. Strobel; modelling of the active site of cytochrome P-450 by means of synthetic analogues, W.D. Woggon; computer modelling of cytochrome P-450 and their substrates - a rational approach to the prediction of carcinogenicity, D.F.V. Lewis; theoretical studies of structure function relationships in cytochrome P-450 - characterization of active sites, reaction mechanisms, substrate-enzyme interactions and stereo-electronic modulators of product distribution, G. Loew and J. Collins; resonance raman spectroscopy of cytochrome P-450, H. Hildebrandt; oxygen activation by heme-containing mono-oxygenases - cytochrome P-450 and secondary amine mono-oxygenase, active site structures and mechanisms of action, B.K. Hawkins and J.H. Dawson; the molecular basis of electron transfer in redox-enzyme systems, N.C. Veitch and R.J.P. Williams; deuterium isotope effect and its significance in cytochrome P-450 catalyzed reactions, A.Y.H. Lu.