Immunogenicity
Wiley (Publisher)
Published on 1. March 1990
Book
Hardback
364 pages
978-0-471-56723-3 (ISBN)
Description
A clear understanding of immunogenicity is necessary for the design of effective vaccines and the avoidance of unnatural immune responses. This study offers a thorough examination of the involved mechanisms of immunogenicity and its practical applications. It focuses on the events that lead to T-cell activation and memory generation, deals with the processing and presentation of antigens to T-cells, examines recognitive and signalling events and covers the processes surrounding lymphocyte activation. There is a full discussion of immunological memory and the role of immunogenicity in infectious diseases, vaccine design, transplantation immunity and autoimmunity.
More details
Language
English
Place of publication
New York
United States
Publishing group
John Wiley and Sons Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
Ill.
Dimensions
Height: 55 mm
Width: 35 mm
Weight
765 gr
ISBN-13
978-0-471-56723-3 (9780471567233)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Editor
Research Institute of Scripps Clinic, California, USA
University of California, Los Angeles, USA
Content
Partial table of contents:; ANTIGEN UPTAKE AND PROCESSING; Where Do Antigens Associate with MHC Class I Molecules?; (J. Yewdell, et al.); THE GENERATION OF AN IMMUNOGENIC LIGAND; Effects of Peptide Competition on Antigen Presentation (L. Adorini, et al.); T CELL RECOGNITION OF ANTIGEN: MHC COMPLEXES; The Role of CD4 in T Cell Activation (S. Goldman, et al.); TRANSMEMBRANE SIGNALING IN LYMPHOCYTES; Regulation of Cytoplasmic Calcium Concentration in T Cells (J. Ledbetter, et al.); THE ROLE OF THE ANTIGEN PRESENTING CELL IN IMMUNOGENICITY; Dendritic Cells: Nature's Adjuvant (R. Steinman, et al.); TOLERANCE: THE INACTIVATION OF LYMPHOCYTES BY SPECIFIC LIGAND; Transgenic Model for Tissue Specific Antigens: Tolerance and Clonal Anergy (D. Lo, et al.); THE GENERATION AND PERSISTENCE OF IMMUNOLOGICAL MEMORY; Immunological Memory: Longlived Cells or Longlived Antigen?; (D. Gray); IMMUNOGENICITY IN DISEASE; Workshop on Immunogenicity in Infectious Diseases (P. Doherty & S. Kaufmann); SYSTEMS QUESTIONS IN IMMUNOGENICITY; Distinct Antigen Presenting Cells for Activation of Suppressor and Contrasuppressor T Cells (H. Braley-Mullen); Index.