Principles of Receptor Research
Published on 24. April 2012
Book
Paperback/Softback
XII, 288 pages
978-1-4684-3170-4 (ISBN)
Description
1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.- 1. Introduction.- 2. Characteristics of the Blood-Brain Barrier.- 3. Bypassing the Blood-Brain Barrier: Principles.- 4. Pharmacological Approach to the Internal or External Surface of the Brain.- 5. Drugs Administered to the Brain Parenchyma.- 6. Concluding Comment.- 7. References.- 2 Microiontophoretic Application of Drugs onto Single Neurons.- 1. Introduction.- 2. Basic Principles.- 3. Dispersal of Iontophoretically Applied Substances Within the Brain.- 4. Conclusions.- 5. References.- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.- 1. Introduction.- 2. Selection of Animal Species.- 3. Acute Experiments.- 4. Chronic Implantation of Electrodes.- 5. Recording Procedures.- 6. Methods of Analyzing and Quantifying the EEG.- 7. Sensory Evoked Response Analysis.- 8. Focal Electrical Stimulation.- 9. Electrogenesis of the EEG and Evoked Potentials.- 10. Assessment of Alertness, Sedation, and the Stages of Sleep.- 11. Study of Sleep Patterns.- 12. Abnormal EEG Records.- 13. Transmitters and EEG Changes.- 14. Uses and Limitations of Macroelectrode Recordings.- 15. References.- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture.- 1. Introduction.- 2. Muscle.- 3. Continuous Cell Lines.- 4. Glia.- 5. Explants.- 6. Dissociated Primary Cell Cultures.- 7. Discussion.- 8. References.- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques.- 1. Introduction.- 2. Properties of Receptor Interactions and Technical Considerations.- 3. Examples of Studies on Hormone-Membrane Receptor Interactions.- 4. Conclusions.- 5. References.- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists.- 1. Introduction.- 2. Norepinephrine.- 3. Dopamine.- 4. 5-Hydroxytryptamine.- 5. Acetylcholine.- 6. Histamine.- 7. References.- 7 Denervation Supersensitivity.- 1. Introduction.- 2. Quantitative Methods in the Study of Supersensitivity.- 3. Surgical and Pharmacological Denervation.- 4. Supersensitivity After Denervation of Sympathetically Innervated Organs.- 5. Supersensitivity After Denervation of Cholinergically Innervated Organs.- 6. Supersensitivity in the Central Nervous System.- 7. Clinical Implications of Supersensitivity and Subsensitivity.- 8. References.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1975
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XII, 288 p.
Dimensions
Height: 254 mm
Width: 178 mm
Thickness: 17 mm
Weight
576 gr
ISBN-13
978-1-4684-3170-4 (9781468431704)
DOI
10.1007/978-1-4684-3168-1
Schweitzer Classification
Other editions
Additional editions
Book
07/1975
Springer
€111.07
Article exhausted; check different version
Content
1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.- 1. Introduction.- 2. Characteristics of the Blood-Brain Barrier.- 3. Bypassing the Blood-Brain Barrier: Principles.- 4. Pharmacological Approach to the Internal or External Surface of the Brain.- 5. Drugs Administered to the Brain Parenchyma.- 6. Concluding Comment.- 7. References.- 2 Microiontophoretic Application of Drugs onto Single Neurons.- 1. Introduction.- 2. Basic Principles.- 3. Dispersal of Iontophoretically Applied Substances Within the Brain.- 4. Conclusions.- 5. References.- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.- 1. Introduction.- 2. Selection of Animal Species.- 3. Acute Experiments.- 4. Chronic Implantation of Electrodes.- 5. Recording Procedures.- 6. Methods of Analyzing and Quantifying the EEG.- 7. Sensory Evoked Response Analysis.- 8. Focal Electrical Stimulation.- 9. Electrogenesis of the EEG and Evoked Potentials.- 10. Assessment of Alertness, Sedation, and the Stages of Sleep.- 11. Study of Sleep Patterns.- 12. Abnormal EEG Records.- 13. Transmitters and EEG Changes.- 14. Uses and Limitations of Macroelectrode Recordings.- 15. References.- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture.- 1. Introduction.- 2. Muscle.- 3. Continuous Cell Lines.- 4. Glia.- 5. Explants.- 6. Dissociated Primary Cell Cultures.- 7. Discussion.- 8. References.- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques.- 1. Introduction.- 2. Properties of Receptor Interactions and Technical Considerations.- 3. Examples of Studies on Hormone-Membrane Receptor Interactions.- 4. Conclusions.- 5. References.- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists.- 1. Introduction.- 2. Norepinephrine.- 3. Dopamine.- 4. 5-Hydroxytryptamine.- 5. Acetylcholine.- 6. Histamine.- 7. References.- 7 Denervation Supersensitivity.- 1. Introduction.- 2. Quantitative Methods in the Study of Supersensitivity.- 3. Surgical and Pharmacological Denervation.- 4. Supersensitivity After Denervation of Sympathetically Innervated Organs.- 5. Supersensitivity After Denervation of Cholinergically Innervated Organs.- 6. Supersensitivity in the Central Nervous System.- 7. Clinical Implications of Supersensitivity and Subsensitivity.- 8. References.