Hedgehog Signaling
From Origins to Therapies
1st Edition
Book
Hardback
400 pages
978-1-118-52483-1 (ISBN)
Description
Hedgehog Signaling: From Origins to Therapies is an in-depth survey of current understanding of Hedgehog signaling biology. Divided into three parts, the book covers mechanisms of action and evolution of the HH pathway; the biological functions of Hh, (principally in vertebrates); and clinical consequences of Hh dysfunction and the modulation of Hh signaling in regenerative medicine and cancer therapy.
Accessible to a wide readership, from advanced students to clinical practicioners, Hedgehog Signaling provides comprehensive coverage of how Hedeghog proteins are processed and secreted, how they are received and interpreted by cells, and the various ways in which they control the proliferation and differentiation of a diverse range of cell types. Designed as a reference for both researchers and clinicians interested in the pathological consequences of Hh dysfunction, as well as its potential for therapeutic applications, Hedgehog Signaling will also be a useful resource for all those interested in cell signalling in development, health and disease.
Accessible to a wide readership, from advanced students to clinical practicioners, Hedgehog Signaling provides comprehensive coverage of how Hedeghog proteins are processed and secreted, how they are received and interpreted by cells, and the various ways in which they control the proliferation and differentiation of a diverse range of cell types. Designed as a reference for both researchers and clinicians interested in the pathological consequences of Hh dysfunction, as well as its potential for therapeutic applications, Hedgehog Signaling will also be a useful resource for all those interested in cell signalling in development, health and disease.
More details
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Dimensions
Height: 284 mm
Width: 228 mm
Thickness: 317 mm
ISBN-13
978-1-118-52483-1 (9781118524831)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
1. Introduction - a brief history of Hh
2. The Hh signaling pathway in Drosophila
3. The evolution of the Hh pathway
4. Production distribution and reception of the HH ligand
5. The Primary Cilium in HH signalling
6. Mechanisms of Hh signaling in mouse
7. Mechanisms of Hh signaling in zebrafish
8. Hh signaling in neural tube patterning in vertebrates
9. Hh signaling in limb development
10. Hh signaling in endodermal organs
11. Hh signaling in myogenesis
12. Hh signaling in skin biology
13. Hh signaling in bone biology
14. Hh signaling in blood and vascular biology
15. Physiological roles of HH
16. Hh signaling in regeneration
17. Hh and human congenital disorders
18. Hh in regenerative medicine
19. Hh in tumorigenesis 1
20. Hh in tumorigenesis 2
21. Hh in tumorigenesis 3
22. Hh therapeutics
Authors:
P Ingham (IMCB, Singapore)
M Scott (Stanford)
P Beachy (Stanford)
P Therond (CNRS, Nice)
A McMahon (Harvard/USC)
J Briscoe (Mill Hill)
M. Placzek (U Sheffield)
C. Tabin (Harvard Med School)
C. Tickle (U Bath)
D. Gummucio (U Michigan)
A-G Borycki (U Sheffield)
A Vortkamp (U Duisberg-Essen)
S Eaton (MPI Dresden)
K Anderson (MSK)
J Reiter (UCSF)
R Toftgard (Karolinska)
N Lawson (U Mass)
T Crompton (ICH, London)
P. Beales (ICH, London)
Y Sasai (Riken, Kobe)
T Curran (U Penn)
A Oro (Stanford)
F de Sauvage (Genentech, San Francisco)
2. The Hh signaling pathway in Drosophila
3. The evolution of the Hh pathway
4. Production distribution and reception of the HH ligand
5. The Primary Cilium in HH signalling
6. Mechanisms of Hh signaling in mouse
7. Mechanisms of Hh signaling in zebrafish
8. Hh signaling in neural tube patterning in vertebrates
9. Hh signaling in limb development
10. Hh signaling in endodermal organs
11. Hh signaling in myogenesis
12. Hh signaling in skin biology
13. Hh signaling in bone biology
14. Hh signaling in blood and vascular biology
15. Physiological roles of HH
16. Hh signaling in regeneration
17. Hh and human congenital disorders
18. Hh in regenerative medicine
19. Hh in tumorigenesis 1
20. Hh in tumorigenesis 2
21. Hh in tumorigenesis 3
22. Hh therapeutics
Authors:
P Ingham (IMCB, Singapore)
M Scott (Stanford)
P Beachy (Stanford)
P Therond (CNRS, Nice)
A McMahon (Harvard/USC)
J Briscoe (Mill Hill)
M. Placzek (U Sheffield)
C. Tabin (Harvard Med School)
C. Tickle (U Bath)
D. Gummucio (U Michigan)
A-G Borycki (U Sheffield)
A Vortkamp (U Duisberg-Essen)
S Eaton (MPI Dresden)
K Anderson (MSK)
J Reiter (UCSF)
R Toftgard (Karolinska)
N Lawson (U Mass)
T Crompton (ICH, London)
P. Beales (ICH, London)
Y Sasai (Riken, Kobe)
T Curran (U Penn)
A Oro (Stanford)
F de Sauvage (Genentech, San Francisco)