Lipid Modification of Proteins
A Practical Approach
Published on 30. July 1992
Book
Paperback/Softback
312 pages
978-0-19-963273-2 (ISBN)
Description
Recent developments have shown that proteins can undergo a diverse range of modifications by lipid which can dramatically effect their structural and functional properties. These modifications include acylation, isoprenylation, and the attachment of glycolipid. Lipid modifications of proteins play important roles in cellular signalling, protein targeting and cellular growth and differentiation - the enzymes which catalyse these reactions are alreadt being seen as
novel therapeutic targets. The biochemical, cell biological, and molecular biological techniques being used in this rapidly expanding field are becoming increasingly sophisticated.
Lipid Modification of Proteins: A Practical Approach is a unique guide to the latest methods in use, written by the acknowledged experts in the field. Detailed protocols are provided for all the key techniques, and the relevant background material is included. This book will be an essential manual for a wide range of scientists studying the modification of protein by lipids, including membrane and protein biochemists, cell biologists, immunologists, bacteriologists, parasitologists,
and virologists.
novel therapeutic targets. The biochemical, cell biological, and molecular biological techniques being used in this rapidly expanding field are becoming increasingly sophisticated.
Lipid Modification of Proteins: A Practical Approach is a unique guide to the latest methods in use, written by the acknowledged experts in the field. Detailed protocols are provided for all the key techniques, and the relevant background material is included. This book will be an essential manual for a wide range of scientists studying the modification of protein by lipids, including membrane and protein biochemists, cell biologists, immunologists, bacteriologists, parasitologists,
and virologists.
Reviews / Votes
'This book is a comprehensive and authoritative collection of the methods that have been employed to detect and characterize these particular lipid modifications. The editors are to be commended for collecting chapters from undoubted leaders in each respective field ... the wealth of information ... is accurate and clearly laid out, and this book represents a useful addition to the 'Practical Approach' series.'C.M. Newman, NIMR, London, Trends in Cell Biology, April 1993, Volume 3, Number 4 'The book is packed with technical details in the now familiar style of the Practical Approach series. It is an excellent and lucid volume with contributions from many of the foremost researchers in the field of lipid modifications, and is clearly intended as a companion in the research laboratory. Since there are no comprehensive tests on lipid-associated proteins, this book will also have a place as a reference volume on the bookshleves of graduate
students and lecturers in many biochemistry and cell biology departments.'
Petr Robinson, Biochemical Education 21(3) 1993
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Target group
Professional and scholarly
Illustrations
halftones, line illustrations, tables
Dimensions
Height: 234 mm
Width: 156 mm
Weight
540 gr
ISBN-13
978-0-19-963273-2 (9780199632732)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Content
A. J. Turner: The diversity of lipid modifications; R. A. J. McIlhinney: Labelling of cell proteins with radioactive fatty acids and methods for studying palmitolyacyl transferase; D. A. Rudnick, R J. Duronio, & J. I. Gordon: Methods for studying myristoyl-CoA: protein N-myristoyltransferase; A. Aitken: Structure determination of acylated proteins; N. M. Hooper: Identification of a glycosyl-phosphatidylinositol anchor of membrane proteins; M. G. Low:
Phospholipases that degrade the glycosyl-phosphatidyl inositol anchor of membr4ane proteins; M. C. Field & A. K menon: Biosynthesis of flycosyl-phosphatidylinositol membrane protein anchors; M. A. J. Ferguson: Chemical and enzymic analysis of glycosyl-phosphatidylinositol anchors; M. H. Gelb, C. C. Farnsworth, & J.
A. Glomset: Structural analysis of prenylated proteins; S. Hayashi & H. C. Wu: Identification and characterization of lipid-modified proteins in bacteria.
Phospholipases that degrade the glycosyl-phosphatidyl inositol anchor of membr4ane proteins; M. C. Field & A. K menon: Biosynthesis of flycosyl-phosphatidylinositol membrane protein anchors; M. A. J. Ferguson: Chemical and enzymic analysis of glycosyl-phosphatidylinositol anchors; M. H. Gelb, C. C. Farnsworth, & J.
A. Glomset: Structural analysis of prenylated proteins; S. Hayashi & H. C. Wu: Identification and characterization of lipid-modified proteins in bacteria.