Patient-Derived Mouse Models of Cancer

In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research.- The revival of patient-derived mouse models of cancer: way back to the future.- Patient-derived xenograft models for human cancer, The Freiburg experience.- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype.- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures.- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice.- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma.- Patient-derived xenograft models of prostate cancer.- Patient-Derived Mouse Models of Sarcoma.- Cervical cancer patient-derived orthotopic xenograft (PDOX) models.- The use of pediatric patient-derived xenografts foridentifying novel agents and combinations.- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics.- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics.- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors.- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model.- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery.- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy.- 3D Cell Culture Models.- Why patient derived mouse models need to be orthotopic.- Foreward: The future of patient-derived models of cancer.