Digital Twins
Description
Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing.
In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them.
This book explains the mathematical structure of digital twins, their development and the model's respective parts, as well as concepts for the knowledge-driven generation and structural variability of digital twins.
Covering fundamentals as well as applications, the two volumes offer the ideal introduction to the topic for researchers in academy and industry alike.
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Persons
Ralf Pörtner studied Chemical Engineering at the University of Dortmund (Germany), and received his Ph.D. at the Department of Mechanical Process Engineering of the same university. After a post-doctoral study at the University of Tsukuba (Japan), he took on the role of Senior Engineer and Head of the working group "Cell Culture and Tissue Engineering" at the Technical University of Hamburg (Germany). Since 2010 he is Honorary Professor at TH Mittelhessen University of Applied Sciences, Giessen (Germany). He is currently one of the coordinators of the research focus "Regeneration, Implants and Medical Technology" of the Technical University of Hamburg (Germany), and member of the directorate of the Research Center Medical Technology (FMTHH). His main research activities include the development of bioreactors, in particular for cell cultures and microbial reactions, as well as model-based control concepts, and tissue engineering.
Johannes Möller studied Bioprocess Engineering at the Hamburg University of Technology (TUHH), Germany, where he did his Ph.D. and worked as a scientist at the Institute of Bioprocess and Biosystems Engineering (Head: Prof. An-Ping Zeng). His research focuses on accelerated and knowledge-driven bioprocess design and optimization using novel statistical and computational methods. The main areas of interest are: Biosystems Engineering, software development for model-assisted bioprocess development and experimental design, and computational methods for bioprocess characterization and control. Since 2020, he joined a pharmaceutical company where he is responsible for the manufacturing of biopharmaceuticals, and he has also worked as an external scientist at TUHH.
Content
Towards the development of digital twins for the biomanufacturing industry.- When is an In silico representation a digital twin? A biopharmaceutical industry approach to the digital twin concept.- Digitalization and bioprocessing, regulatory aspects.- Usage of Digital Twins along a typical process development cycle.- Mechanistic Mathematical Models as a Basis for Process Optimization and Digital Twins.- Digital Seed Train Twins and Statistical Methods.- Digital Twins in Biomanufacturing.