Lipids
Biochemistry, Biotechnology and Health
6th Edition
Published on 26. August 2016
Book
Paperback/Softback
448 pages
978-1-118-50113-9 (ISBN)
Description
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research - have not changed since previous editions.
Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry.
An introductory chapter summarizes the types of lipids covered and their identification and provides a guide to the contents. Chapters contain boxes illustrating special topics, key point summaries and suggested further reading.
Lipids: Sixth Edition provides a huge wealth of information for upper-level students of biological and clinical sciences, food science and nutrition, and for professionals working in academic and industrial research. Libraries in all universities and research establishments where biological, medical and food and nutritional sciences are studied and taught should have copies of this excellent and comprehensive new edition on their shelves.
Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry.
An introductory chapter summarizes the types of lipids covered and their identification and provides a guide to the contents. Chapters contain boxes illustrating special topics, key point summaries and suggested further reading.
Lipids: Sixth Edition provides a huge wealth of information for upper-level students of biological and clinical sciences, food science and nutrition, and for professionals working in academic and industrial research. Libraries in all universities and research establishments where biological, medical and food and nutritional sciences are studied and taught should have copies of this excellent and comprehensive new edition on their shelves.
More details
Edition
6th edition
Language
English
Place of publication
Hoboken
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
Professional and scholarly
College/higher education
Dimensions
Height: 246 mm
Width: 189 mm
Thickness: 24 mm
Weight
860 gr
ISBN-13
978-1-118-50113-9 (9781118501139)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
06/2016
6th Edition
Wiley-Blackwell
€66.99
Available for download
E-Book
06/2016
6th Edition
Wiley-Blackwell
€66.99
Available for download
Previous edition
Book
04/2002
Wiley
€124.06
Article exhausted; check for reprint
Persons
Michael Gurr was Visiting Professor in Human Nutrition at Reading and Oxford Brookes Universities, UK.
John Harwood is a Professor of Biochemistry, School of Biosciences, Cardiff University, UK.
Keith Frayn is Emeritus Professor of Human Metabolism, University of Oxford, UK.
Denis Murphy is Professor of Biotechnology, School of Applied Sciences, University of South Wales, UK.
Robert Michell is Professor of Biochemistry, School of Biosciences, University of Birmingham, UK.
John Harwood is a Professor of Biochemistry, School of Biosciences, Cardiff University, UK.
Keith Frayn is Emeritus Professor of Human Metabolism, University of Oxford, UK.
Denis Murphy is Professor of Biotechnology, School of Applied Sciences, University of South Wales, UK.
Robert Michell is Professor of Biochemistry, School of Biosciences, University of Birmingham, UK.
Content
Preface xv
Acknowledgements xvii
About the authors xix
About the companion website xxi
1 Lipids: definitions naming methods and a guide to the contents of this book 1
1.1 Introduction 1
1.2 Definitions 1
1.3 Structural chemistry and nomenclature 1
1.4 Lipidomics 4
1.5 A guide to the contents of this book 8
Key points 11
Further reading 12
2 Important biological lipids and their structures 13
2.1 Structure and properties of fatty acids 13
2.2 Storage lipids - triacylglycerols and wax esters 20
2.3 Membrane lipids 26
Key points 42
Further reading 42
3 Fatty acid metabolism 44
3.1 The biosynthesis of fatty acids 44
3.2 Degradation of fatty acids 85
3.3 Chemical peroxidation is an important reaction particularly of polyunsaturated fatty acids 95
3.4 Peroxidation catalysed by lipoxygenase enzymes 96
3.5 Essential fatty acids and the biosynthesis of eicosanoids 100
Key points 120
Further reading 121
4 The metabolism of complex lipids 124
4.1 The biosynthesis of triacylglycerols 124
4.2 The catabolism of acylglycerols 133
4.3 The integration and control of animal acylglycerol metabolism 136
4.4 Wax esters 143
4.5 Phosphoglyceride biosynthesis 146
4.6 Degradation of phospholipids 157
4.7 Metabolism of glycosylglycerides 163
4.8 Metabolism of sphingolipids 165
4.9 Cholesterol biosynthesis 173
Key points 182
Further reading 183
5 Roles of lipids in cellular structures 187
5.1 Lipid assemblies 187
5.2 Role of lipids in cellular evolution 193
5.3 Membrane structure 201
5.4 Membrane function 206
5.5 Intracellular lipid droplets 215
5.6 Extracellular lipid assemblies 222
Key points 226
Further reading 227
6 Dietary lipids and their biological roles 229
6.1 Lipids in food 229
6.2 Roles of dietary lipids 233
Key points 251
Further reading 251
7 Lipid assimilation and transport 253
7.1 Lipid digestion and absorption 253
7.2 Transport of lipids in the blood: plasma lipoproteins 261
7.3 The coordination of lipid metabolism in the body 275
Key points 284
Further reading 285
8 Lipids in transmembrane signalling and cell regulation 287
8.1 Phosphoinositides have diverse roles in cell signalling and cell compartmentation 288
8.2 Endocannabinoid signalling 299
8.3 Lysophosphatidate and sphingosine 1-phosphate in the circulation regulate cell motility and proliferation 299
8.4 Signalling by phospholipase D at least partly through phosphatidate 300
8.5 Ceramide regulates apoptosis and other cell responses 301
Key points 302
Further reading 303
9 The storage of triacylglycerols in animals and plants 304
9.1 White adipose tissue depots and triacylglycerol storage in animals 304
9.2 Brown adipose tissue and its role in thermogenesis 310
9.3 Lipid storage in plants 313
Key points 314
Further reading 315
10 Lipids in health and disease 317
10.1 Inborn errors of lipid metabolism 317
10.2 Lipids and cancer 323
10.3 Lipids and immune function 328
10.4 Effects of too much or too little adipose tissue: obesity and lipodystrophies 338
10.5 Disorders of lipoprotein metabolism 349
Key points 364
Further reading 365
11 Lipid technology and biotechnology 367
11.1 Introduction 367
11.2 Lipid technologies: from surfactants to biofuels 367
11.3 Lipids in foods 375
11.4 Modifiying lipids in foods 379
11.5 Modifying lipids in nonedible products 383
11.6 Lipids and genetically modified organisms 385
Key points 390
Further reading 390
Index and list of abbreviations 391
Acknowledgements xvii
About the authors xix
About the companion website xxi
1 Lipids: definitions naming methods and a guide to the contents of this book 1
1.1 Introduction 1
1.2 Definitions 1
1.3 Structural chemistry and nomenclature 1
1.4 Lipidomics 4
1.5 A guide to the contents of this book 8
Key points 11
Further reading 12
2 Important biological lipids and their structures 13
2.1 Structure and properties of fatty acids 13
2.2 Storage lipids - triacylglycerols and wax esters 20
2.3 Membrane lipids 26
Key points 42
Further reading 42
3 Fatty acid metabolism 44
3.1 The biosynthesis of fatty acids 44
3.2 Degradation of fatty acids 85
3.3 Chemical peroxidation is an important reaction particularly of polyunsaturated fatty acids 95
3.4 Peroxidation catalysed by lipoxygenase enzymes 96
3.5 Essential fatty acids and the biosynthesis of eicosanoids 100
Key points 120
Further reading 121
4 The metabolism of complex lipids 124
4.1 The biosynthesis of triacylglycerols 124
4.2 The catabolism of acylglycerols 133
4.3 The integration and control of animal acylglycerol metabolism 136
4.4 Wax esters 143
4.5 Phosphoglyceride biosynthesis 146
4.6 Degradation of phospholipids 157
4.7 Metabolism of glycosylglycerides 163
4.8 Metabolism of sphingolipids 165
4.9 Cholesterol biosynthesis 173
Key points 182
Further reading 183
5 Roles of lipids in cellular structures 187
5.1 Lipid assemblies 187
5.2 Role of lipids in cellular evolution 193
5.3 Membrane structure 201
5.4 Membrane function 206
5.5 Intracellular lipid droplets 215
5.6 Extracellular lipid assemblies 222
Key points 226
Further reading 227
6 Dietary lipids and their biological roles 229
6.1 Lipids in food 229
6.2 Roles of dietary lipids 233
Key points 251
Further reading 251
7 Lipid assimilation and transport 253
7.1 Lipid digestion and absorption 253
7.2 Transport of lipids in the blood: plasma lipoproteins 261
7.3 The coordination of lipid metabolism in the body 275
Key points 284
Further reading 285
8 Lipids in transmembrane signalling and cell regulation 287
8.1 Phosphoinositides have diverse roles in cell signalling and cell compartmentation 288
8.2 Endocannabinoid signalling 299
8.3 Lysophosphatidate and sphingosine 1-phosphate in the circulation regulate cell motility and proliferation 299
8.4 Signalling by phospholipase D at least partly through phosphatidate 300
8.5 Ceramide regulates apoptosis and other cell responses 301
Key points 302
Further reading 303
9 The storage of triacylglycerols in animals and plants 304
9.1 White adipose tissue depots and triacylglycerol storage in animals 304
9.2 Brown adipose tissue and its role in thermogenesis 310
9.3 Lipid storage in plants 313
Key points 314
Further reading 315
10 Lipids in health and disease 317
10.1 Inborn errors of lipid metabolism 317
10.2 Lipids and cancer 323
10.3 Lipids and immune function 328
10.4 Effects of too much or too little adipose tissue: obesity and lipodystrophies 338
10.5 Disorders of lipoprotein metabolism 349
Key points 364
Further reading 365
11 Lipid technology and biotechnology 367
11.1 Introduction 367
11.2 Lipid technologies: from surfactants to biofuels 367
11.3 Lipids in foods 375
11.4 Modifiying lipids in foods 379
11.5 Modifying lipids in nonedible products 383
11.6 Lipids and genetically modified organisms 385
Key points 390
Further reading 390
Index and list of abbreviations 391