
Cellular Senescence and Cardiac Aging
Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases
Elsevier (Publisher)
Will be published approx. on 1. September 2026
Book
Paperback/Softback
280 pages
978-0-443-45811-8 (ISBN)
Description
Cellular Senescence and Cardiac Aging: Mechanisms, Therapeutic Strategies, and Implications for Cardiovascular Diseases offers a comprehensive and up-to-date exploration of the molecular and cellular processes driving cardiac aging, with a special focus on cellular senescence. This authoritative volume bridges cutting-edge, basic science with clinical applications, detailing how senescent cells contribute to age-related cardiovascular diseases and highlighting innovative therapeutic approaches such as senolytics and regenerative medicine. Ideal for graduate students, researchers, and clinicians in biomedical sciences, cardiology, pharmacology, and regenerative medicine, this book provides essential insights into biomarkers, epigenetics, autophagy, and emerging treatments.
With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.
With contributions from global experts, it also addresses gender and ethnic disparities, ensuring a broad and inclusive perspective. This indispensable resource equips readers with the knowledge needed to advance research and improve patient care in the rapidly evolving field of cardiac aging.
More details
Content
1. Introduction to Cardiac Aging and Cellular Senescence
2. Molecular Mechanisms of Senescence in Cardiomyocytes
3. Senescence-Associated Secretory Phenotype (SASP) in Cardiac Tissue
4. Mitochondrial Dysfunction, Oxidative Stress, and Cardiac Aging
5. Telomere Attrition and Cardiovascular Senescence
6. Epigenetic Modifications in Cardiac Aging and Senescence
7. Autophagy, Mitophagy, and Senescence in the Heart
8. Senescence-Induced Cardiac Fibrosis and Remodeling
9. Senolytics and Senomorphics: Emerging Therapeutic Strategies
10. Biomarkers of Senescence in Cardiovascular Diseases
11. Regenerative Medicine and Stem Cell Approaches in Cardiac Aging
12. Metabolic Disorders, Obesity, and Accelerated Cardiac Senescence
13. Gender Differences and Ethnic Disparities in Cardiac Aging
14. Clinical Trials and Translational Advances Targeting Cardiac Aging
15. Future Perspectives: Personalized Medicine and Senescence Modulation in Cardiovascular Health
2. Molecular Mechanisms of Senescence in Cardiomyocytes
3. Senescence-Associated Secretory Phenotype (SASP) in Cardiac Tissue
4. Mitochondrial Dysfunction, Oxidative Stress, and Cardiac Aging
5. Telomere Attrition and Cardiovascular Senescence
6. Epigenetic Modifications in Cardiac Aging and Senescence
7. Autophagy, Mitophagy, and Senescence in the Heart
8. Senescence-Induced Cardiac Fibrosis and Remodeling
9. Senolytics and Senomorphics: Emerging Therapeutic Strategies
10. Biomarkers of Senescence in Cardiovascular Diseases
11. Regenerative Medicine and Stem Cell Approaches in Cardiac Aging
12. Metabolic Disorders, Obesity, and Accelerated Cardiac Senescence
13. Gender Differences and Ethnic Disparities in Cardiac Aging
14. Clinical Trials and Translational Advances Targeting Cardiac Aging
15. Future Perspectives: Personalized Medicine and Senescence Modulation in Cardiovascular Health