Molecular Basis of Sex Hormone Receptor Function
New Targets for Intervention
Published on 1. September 1998
Book
Hardback
XIV, 238 pages
978-3-540-64702-7 (ISBN)
Description
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.
More details
Series
Language
English
Place of publication
Heidelberg
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Illustrations
58
3 s/w Tabellen, 58 s/w Abbildungen
58 black & white illustrations, 3 black & white tables, biography
Weight
456 gr
ISBN-13
978-3-540-64702-7 (9783540647027)
DOI
10.1007/978-3-662-03689-1
Schweitzer Classification
Other editions
Additional editions
Hinrich Gronemeyer | Ulrike Fuhrmann | Karsten Parczyk
Molecular Basis of Sex Hormone Receptor Function
New Targets for Intervention
Book
10/2013
Springer
€53.49
Shipment within 7-9 days
Hinrich Gronemeyer | Ulrike Fuhrmann | Karsten Parczyk
Molecular Basis of Sex Hormone Receptor Function
New Targets for Intervention
E-Book
04/2013
Springer
€53.49
Available for download
Content
From the contents:
Nuclear Receptors as Targets for Drug Design: New Options and Old Challenges.- The Androgen Receptor Coregulator ARA70.- Role of Coactivators in Transcriptional Activation by Estrogen Receptors.- A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids.- Activation of Progesterone and Androgen Receptors by Signal Transduction Pathways.- Ligand-Independent Activation of the Estrogen Receptor: Activation by EGF and Dopamine.- The ER/API Pathway: A Window on the Cell Specific Estrogen-like Effects of Antiestrogens - A Structural View of the Retinoid Nuclear Receptors.- Characterisation of Human Estrogen Receptors ß (ERß).- Functional and Pharmacological Analysis of the A and B-Forms of the Human Progesterone Receptor.- Oestrogen Receptor Expression Mutants and Variants in Tamoxifen Resistant Breast Cancer.- Structure and Expression of the AR in Prostate Cancer.
Nuclear Receptors as Targets for Drug Design: New Options and Old Challenges.- The Androgen Receptor Coregulator ARA70.- Role of Coactivators in Transcriptional Activation by Estrogen Receptors.- A Search for a Mechanism for the Antiinflammatory Action of Glucocorticoids.- Activation of Progesterone and Androgen Receptors by Signal Transduction Pathways.- Ligand-Independent Activation of the Estrogen Receptor: Activation by EGF and Dopamine.- The ER/API Pathway: A Window on the Cell Specific Estrogen-like Effects of Antiestrogens - A Structural View of the Retinoid Nuclear Receptors.- Characterisation of Human Estrogen Receptors ß (ERß).- Functional and Pharmacological Analysis of the A and B-Forms of the Human Progesterone Receptor.- Oestrogen Receptor Expression Mutants and Variants in Tamoxifen Resistant Breast Cancer.- Structure and Expression of the AR in Prostate Cancer.