Biochemistry of Pulmonary Emphysema
Published on 9. April 2014
Book
Paperback/Softback
XV, 200 pages
978-1-4471-3773-3 (ISBN)
Description
Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1992
Language
English
Place of publication
London
United Kingdom
Target group
Professional and scholarly
Research
Illustrations
13 s/w Abbildungen
XV, 200 p. 13 illus.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 13 mm
Weight
389 gr
ISBN-13
978-1-4471-3773-3 (9781447137733)
DOI
10.1007/978-1-4471-3771-9
Schweitzer Classification
Other editions
Additional editions
C. Grassi | J. Travis | L. Casali
Biochemistry of Pulmonary Emphysema
E-Book
11/2013
Springer
€53.49
Available for download
C. Grassi | J. Travis | L. Casali
Biochemistry of Pulmonary Emphysema
Book
10/1992
Springer
€85.59
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Persons
Content
From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.