Issues in Association Analysis
Special Issue: "Human Heredity 2004, Volume 58, Number 3-4". Special Topic Issue: Human Heredity 2004, Vol. 58, No. 3-4
Published on 17. March 2005
Book
Paperback/Softback
90 pages
978-3-8055-7924-7 (ISBN)
Description
This special issue of Human Heredity discusses a wide range of current topics related to genetic disease association analysis. Topics covered include phenotype definition, genotype-phenotype correlation, and strategies for managing phenotypic data, multipoint methods for genotype error detection, as well as the robustness of genomic control methods for case/control association in admixed populations. Further addressed are the relative costs for different types of genotype errors in genetic model-based association, a comprehensive review of optimal SNP marker selection in disease association, and the comparative information of multiple SNPs and single microsatellites.
Anyone involved in complex genetic research, i.e. clinicians, geneticists and statistical geneticists, will find guidance on study design, on how to evaluate phenotypes used in linkage and association findings, and on how to avoid pitfalls that typically arise in genetic studies.
Anyone involved in complex genetic research, i.e. clinicians, geneticists and statistical geneticists, will find guidance on study design, on how to evaluate phenotypes used in linkage and association findings, and on how to avoid pitfalls that typically arise in genetic studies.
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Content
Introduction: McMahon, F.J.; Schulze, T.G.; Gordon, D. Computer-Assisted Phenotype Characterization for Genetic Research in Psychiatry: Fangerau, H.; Ohlraun, S.; Granath, R.O.; Nothen, M.M.; Rietschel, M.; Schulze, T.G. Defining the Phenotype in Human Genetic Studies: Forward Genetics and Reverse Phenotyping: Schulze, T.G.; McMahon, F.J. Quantifying the Percent Increase in Minimum Sample Size for SNP Genotyping Errors in Genetic Model-Based Association Studies: Kang, S.J.; Finch, S.J.; Haynes, C.; Gordon, D. Case-Control Association Studies in Mixed Populations: Correcting Using Genomic Control: Shmulewitz, D.; Zhang, J.; Greenberg, D.A. Incorporating Individual Error Rate into Association Test of Unmatched Case-Control Design: Hao, K.; Wang, X. Comparative Informativeness for Linkage of Multiple SNPs and Single Microsatellites: Lindholm, E.; Hodge, S.E.; Greenberg, D.A. Issues in Association Analysis: Error Control in Case-Control Association Studies for Disease Gene Discovery: Ott, J. Comparative Study of Multipoint Methods for Genotype Error Detection: Mukhopadhyay, N.; Buxbaum, S.G.; Weeks, D.E. Optimal Selection of SNP Markers for Disease Association Studies: Halldorsson, B.V.; Istrail, S.; De La Vega, F.M. Author and Subject Index