Advances in Family-Based Association Analysis
15 Years of Practical Experience with the Original Transmission Disequilibrium Test. Special Topic Issue: Human Heredity 2008, Vol. 66, No. 2
1st Edition
Published on 21. April 2008
Book
Paperback/Softback
76 pages
978-3-8055-8557-6 (ISBN)
Description
This special issue celebrates the anniversary of the seminal publication introducing the transmission disequilibrium test (TDT) as a method for testing linkage and association in family data. It features a series of reviews and methodological papers by noted researchers in the field, each of whom has made advances in family-based association testing. Anyone performing family-based association testing and those who wish to learn more about the history regarding the development of the TDT will appreciate the additional investigations of the TDT statistic presented in this issue.
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Content
Introduction: Gordon, D.; Devoto, M.; Review and Evaluation of Methods Correcting for Population Stratification with a Focus on Underlying Statistical Principles: Tiwari, H.K.; Barnholtz-Sloan, J.; Wineinger, N.; Padilla, M.A.; Vaughan, L.K.; Allison, D.B.; Likelihood-Based Association Analysis for Nuclear Families and Unrelated Subjects with Missing Genotype Data: Dudbridge, F.; A Family-Based Likelihood Ratio Test for General Pedigree Structures That Allows for Genotyping Error and Missing Data: Yang, Y.; Wise, C.A.; Gordon, D.; Finch, S.J.; Estimating Relative Risks from Significant Family-Based Association Studies: Knapp, M.; FBAT-SNP-PC: An Approach for Multiple Markers and Single Trait in Family-Based Association Tests: Rakovski, C.S.; Weiss, S.T.; Laird, N.M.; Lange, C.; The Future Is Now - Will the Real Disease Gene Please Stand Up?: Martin, E.R.; Schmidt, M.A.; Author Index; Subject Index.