Basic Clinical Radiobiology
2nd Edition
Published on 26. September 1997
Book
Hardback
264 pages
978-0-340-70020-4 (ISBN)
Description
This is a basic teaching book for radiation oncologists, radiation physicists, and radiobiologists, setting out the biological basis of radiation therapy. Early chapters deal with essential areas of science, including cell proliferation in tumours and normal tissues, principles of radiation cell killing, theoretical and modelling approaches, and molecular aspects of radiobiology. Subsequent chapters deal with the applications of radiobiology to clinical radiotherapy. The principles of fractionalism are described in detail, leading to the rationale of current approaches to the improvement of radiotherapy schedules. Also discussed are efforts to beat hypoxia in tumours, brachytherapy, the principles and use of particle beams, the combination of radiotherapy and chemotherapy, hyperthermia, targeted radiotherapy, and current efforts to individualize treatment with radiation therapy. This second edition has been updated and expanded to include advances in molecular growth. Each chapter concludes with a list of key points, and there are frequent cross-references between chapters.
More details
Edition
2nd New edition
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
College/higher education
Professional and scholarly
Edition type
New edition
Illustrations
242 b/w illus
ISBN-13
978-0-340-70020-4 (9780340700204)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Book
07/2002
3rd Edition
Hodder Arnold
€76.94
Article exhausted; check for reprint
Previous edition
G.G. Steel
Basic Clinical Radiobiology
Book
11/1993
Hodder Arnold
€57.08
Article exhausted; check for reprint
Content
Introduction - the significance of radiobiology for radiotherapy; the growth of tumours; cell proliferation in tumours; proliferative and cellular organization of normal tumours; radiation response and tolerance of normal tissues; clonogenic cells and the concept of cell survival; models of radiation cell killing; DNA damage and cell killing; genetic control for the cellular response to ionizing radiation; dose-response relationships in radiotherapy; clinical manifestations of normal-tissue damage; time-dose relationships in radiotherapy; the linear-quadratic approach to fractionation and calculation of isoeffect relationships; hyperfractionation and accelerated radiotherapy; the oxygen effect; overcoming hypoxic radioresistance; the radiobiology of tumours; the dose-rate effect - brachytherapy; particle beams in radiotherapy; combination of radiotherapy and chemotherapy - principles; combination of radiotherapy and chemotherapy - clinical application and evaluation; re-treatment tolerance of normal tissues; hyperthermia; targeted radiotherapy; individualization of radiotherapy.