Regulation of Angiogenesis
Published on 27. September 2011
Book
Paperback/Softback
X, 436 pages
978-3-0348-9864-5 (ISBN)
Description
thrombospondin-l may be encoded by a tumor suppressor gene. Dr. O'Reilly discusses angiostatin, an exciting recently discovered factor derived from the fibrinolytic proenzyme plasminogen that inhibits tumor angiogenesis, primary tumor growth, and formation of metastases. In addition to the soluble class of angiogenesis-regulatory factors discussed above, interactions of endothelial cells with components of the extracellular matrix and with other cell types are critical for proper formation of vessels. Drs. Grant and Kleinman discuss the role of laminin and other matrix molecules in regulation of capillary formation. Dr. van Hinsbergh and colleagues describe the role of fibrin and the fibrinolytic system in angiogenesis associated with wound repair. Cell surface mole- cules that interact with the extracellular matrix have been implicated in the regulation of angiogenesis. Dr. Varner discusses some exciting new studies on the roles of specific vascular cell integrins (a /33 and a /3s) in mediating v v tumor angiogenesis and angiogenesis associated with wound healing.
The pericyte, a vascular smooth muscle-like cell, exerts a powerful regulatory effect during the later stages of angiogenesis in which mature capillaries are formed. These mechanisms are discussed by Drs. Hirschi and D' Amore. With all the recent progress in the molecular biology of angiogenesis, the contribution of microenvironmental conditions such as hypoxia and pH to angiogenesis is often ignored. Drs. Rockwell and Knisely review this area of investigation and present studies of experimental tumor models.
The pericyte, a vascular smooth muscle-like cell, exerts a powerful regulatory effect during the later stages of angiogenesis in which mature capillaries are formed. These mechanisms are discussed by Drs. Hirschi and D' Amore. With all the recent progress in the molecular biology of angiogenesis, the contribution of microenvironmental conditions such as hypoxia and pH to angiogenesis is often ignored. Drs. Rockwell and Knisely review this area of investigation and present studies of experimental tumor models.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1997
Language
English
Place of publication
Basel
Switzerland
Publishing group
Springer Basel
Target group
Professional and scholarly
Research
Illustrations
X, 436 p.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 25 mm
Weight
768 gr
ISBN-13
978-3-0348-9864-5 (9783034898645)
DOI
10.1007/978-3-0348-9006-9
Schweitzer Classification
Other editions
Additional editions
I.D. Goldberg | E.R. Rosen
Regulation of Angiogenesis
Book
12/1996
Birkhäuser
€85.55
Article exhausted; check different version
Content
Angiogenesis and angiogenesis inhibition: An overview.- Significance of angiogenesis in human disease.- Role of the macrophage in angiogenesis-dependent diseases.- Angiogenesis in human gliomas: Prognostic and therapeutic implications.- Regulation of angiogenesis in malignant gliomas.- Lymphangiogenesis: Mechanisms, significance and clinical implications.- Angiogenesis as a biologic and prognostic indicator in human breast carcinoma.- Molecular mechanisms of angiogenesis regulation.- Control of angiogenesis by cytokines and growth factors.- Fibroblast growth factors as angiogenesis factors: New insights into their mechanism of action.- Regulation of angiogenesis by scatter factor.- Vascular endothelial growth factor: Basic biology and clinical implications.- Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine.- Angiogenesis inhibition.- Angiostatin: An endogenous inhibitor of angiogenesis and of tumor growth.- Thrombospondin as a regulator of angiogenesis.- Regulation of angiogenesis by cell-matrix cell-cell and other interactions.- Regulation of capillary formation by laminin and other components of the extracellular matrix.- Hypoxia and angiogenesis in experimental tumor models: Therapeutic implications.- The role of vascular cell integrins ?v?3 and ?v?5 in angiogenesis.- Role of fibrin and plasminogen activators in repair-associated angiogenesis: In vitro studies with human endothelial cells.- Tumor angiogenesis: Functional similarities with tumor invasion.- Control of angiogenesis by the pericyte: Molecular mechanisms and significance.