Failure of Apoptosis and Cancer Metastasis
Published on 13. November 1998
Book
Hardback
XVII, 178 pages
978-3-540-64560-3 (ISBN)
Description
This book summarizes recent reports on adhesion-dependent regulation of apoptosis. The author discusses data indicating that highly metastatic cancer cells exhibit a superior survival ability and resistance to apoptosis induced by diverse external signals. He also shows that increased survival of metastatic cancer cells compared to nonmetastatic or poorly metastatic cells is associated with their enhanced galectin-mediated homotypic aggregation and dysfunction of adhesion-dependent regulation of apoptosis. Profound deficiency of two major apoptosis execution mechanisms has been identified as a main characteristic of apoptosis failure in metastatic cancer cells.
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Content
Cell adhesion cascade as a multicomponent and multistep process.- Apoptosis and metastasis: Failure of apoptosis in metastatic cancer cells as a key factor of metastatic disease.- Apoptosis resistance of metastatic cancer cells is associated with deficiency of apoptosis execution mechanisms.- A hypothesis for telomere-dependent control of apoptosis.- Inhibition of homotypic cancer cell aggregation and colony formation in agarose of metastatic human cancer cells by synthetic glycoamine analogs.- Inhibition of human breast cancer metastasis in nude mice by synthetic glycoamines.