Regenerative Medicine Translation

Dr. Gimble's laboratory focuses on the isolation and characterization of adult stem cells from adipose tissue and bone marrow. These stromal cells have multiple differentiation potential and are capable of forming adipocytes, chondrocytes, hematopoietic supporting cells, neuronal cells, and osteoblasts in vitro. We are exploring the regulatory mechanisms governing the adult stem cell's fate and how they can be applied to regenerative medical problems. Dr. Bunnell is interested in cell and gene therapies for lysosomal storage diseases, specifically Krabbe's and Sandhoff's disease. His group has isolated and is characterizing mouse and nonhuman primate mesenchymal stem cells from both bone marrow and adipose tissues. His laboratory group is currently working to define the biologic properties and differentiation potential of these distinct populations. His laboratory has also successfully isolated neural stem cells from the brain of nonhuman primates. He is presently focused on delineating the similarities and major differences between mesenchymal and neural stem cells for the treatment of these diseases in the CNS.