Genetics of Sleep and Sleep Disorders
Description
This book focuses on the latest research on the genetic basis of the regulation of sleep and wakefulness and of sleep and circadian rhythm disorders, which has been expanding rapidly due to advances in genetics. The book reviews the latest genetic discoveries in animals and humans and explores their implications for getting a good night's sleep. Philp Gehrman, Alex Keene, Struan Grant, and a cadre of top sleep researchers and clinicians explore the genetics of sleep and sleep disorders in depth. The book should appeal to sleep medicine specialists, psychiatrists, geneticists, and neuroscientists.
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Persons
Alex Keene, PhD, is Professor and Head, Department of Biology, Texas A&M University, College Station, Texas
Struan Grant, PhD, is Co-Director of the Center for Spatial and Functional Genomics, the Daniel B. Burke Endowed Chair for Diabetes Research, and the Emeritus Associate Director of the Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Content
Introduction.- Section I: Animal Models. - Drosophila.- C Elegans.- Zebrafish.- Cavefish.- Mouse models.- Cnidarian sleep.- Section II: Human Sleep and Sleep disorders .- Approaches to studying human genetics.- Mendelian randomization studies of sleep and circadian traits.- Insomnia.- Chronotype / Circadian rhythm disorders.- Narcolepsy and Hypersomnia.- Restless Legs Syndrome.- Section III: Other topics .- Genetics of the circadian clock.- Genetic predictors of the response to sleep loss.- Sleep and neurodevelopment/ genetic developmental disorders.- Genetic Studies of Sleep in Children.- Sleep and memory.