Hurst's the Heart, 14th Edition: Two Volume Set

Contributorsxi

Prefacexxv

Abbreviationsxxvii




Volume One

SECTION 1

Cardiovascular Disease: Past, Present, and Future

1.A History of the Cardiac Diseases, and

the Development of Cardiovascular Medicine

as a Specialty3

Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley

2.The Global Burden of Cardiovascular Diseases19

Catherine P. Benziger, Andrew E. Moran, and Gregory A. Roth

3.Assessing and Improving the Quality of Care

in Cardiovascular Medicine52

Yashashwi Pokharel and John A. Spertus




SECTION 2

Foundations of Cardiovascular Medicine

4.Functional Anatomy of the Heart67

Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward

5.Normal Physiology of the

Cardiovascular System101

Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez

6.Molecular and Cellular Biology of the Heart125

Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum

7.Biology of the Vessel Wall144

Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic

8.Molecular and Cellular Development

of the Heart161

Miguel Torres and Silvia Martin-Puig

9.Genetic Basis of Cardiovascular Disease174

Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso

v

10.Stem Cells and the Cardiovascular System205

Karim Sallam and Joseph C. Wu




SECTION 3

Evaluation of the Patient

11.The History, Physical Examination, and

Cardiac Auscultation225

William R. Miranda and Rick A. Nishimura

12.Surface Electrocardiography252

Antoni Bayes de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayes-Genis

13.Electrocardiographic Exercise Testing318

Gregory S. Thomas and Myrvin H. Ellestad

14.Cardiac Radiography335

Geoffrey D. Rubin

15.Echocardiography353

Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A. Zoghbi

16.Magnetic Resonance Imaging of the Heart433

W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz

17.Computed Tomography of the Heart469

Amir Ahmadi, Jagat Narula, and Jonathon Leipsic

18.Nuclear Cardiology499

Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, Piotr J. Slomka, Guido Germano,

and Jagat Narula

19.Positron Emission Tomography

in Heart Disease553

K. Lance Gould, Heinrich Schelbert, and Jagat Narula

20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure

Measurements606

Morton J. Kern and Arnold H. Seto

21.Coronary Intravascular Imaging657

Christos V. Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys

22.Magnetic Resonance Imaging

and Computed Tomography of the

Vascular System686

Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad



viContents

SECTION 4

Systemic Arterial Hypertension

23.Epidemiology of Hypertension703

Nathan D. Wong and Stanley S. Franklin


24.Pathophysiology of Hypertension720

John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall

25.Diagnosis and Treatment of Hypertension751

Lawrence R. Krakoff




SECTION 5

Metabolic Disorders and Cardiovascular Disease

26.The Metabolic Syndrome767

Michael A. Via and Jeffrey I. Mechanick

27.Obesity and Cardiovascular Disease776

W. Timothy Garvey and Jeffrey I. Mechanick

28.Diabetes and Cardiovascular Disease789

Michael E. Farkouh, Elliot J. Rayfield, and Valentin Fuster

29.Hyperlipidemia817

Robert S. Rosenson and Scott M. Grundy




SECTION 6

Cigarette Smoking and Cardiovascular Diseases

30.Epidemiology of Smoking and Pathophysiology

of Cardiovascular Damage849

Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster

31.Preventing and Mitigating Smoking-Related

Heart Disease860

Sara Kalkhoran and Stanton Glantz




SECTION 7

Atherosclerosis and Coronary Heart Disease

32.Atherothrombosis: Disease Burden, Activity,

and Vulnerability871

Erling Falk and Valentin Fuster

33.Coronary Thrombosis: Local

and Systemic Factors880

Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon

34.Coronary Blood Flow and Myocardial

Ischemia893

K. Lance Gould, Henry Gewirtz, and Jagat Narula

35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary

Heart Disease923

David E. Winchester and Carl J. Pepine

36.Definitions of Acute Coronary Syndromes946

Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster

37.Pathology of Myocardial Infarction

and Sudden Death954

Maria E. Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani

38.Molecular and Cellular Mechanisms

of Myocardial Ischemia/Reperfusion Injury977

Borja Ibanez, Gerd Heusch, David Garcia-Dorado, Valentin Fuster, and Derek Yellon

39.Evaluation and Management of Non-ST-Segment Elevation

Myocardial Infarction995

David J. Moliterno and James L. Januzzi, Jr.

40.ST-Segment Elevation Myocardial Infarction ... 1017

Manesh R. Patel, Mandeep Singh, Bernard J. Gersh, and William O'Neill

41.Antiplatelet and Anticoagulant Therapy

in Acute Coronary Syndromes1055

Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran

42.Percutaneous Coronary Interventions in Acute Myocardial Infarction

and Acute Coronary Syndromes1109

William O'Neill, Cindy Grines, and George Dangas

43.The Evaluation and Management

of Stable Ischemic Heart Disease1132

Bradley A. Maron, Bernard J. Gersh, and Patrick T. O'Gara

44.Coronary Artery Bypass Grafting

and Percutaneous Interventions in Stable

Ischemic Heart Disease1160

Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas,

and Valentin Fuster

45.Rehabilitation of the Patient with Coronary

Heart Disease1173

Mary Ann McLaughlin



Contentsvii

SECTION 8

Valvular Heart Disease

46.Acute Rheumatic Fever1187

Liesl Zuehlke, Jagat Narula, and Jonathan R. Carapetis

47.Aortic Valve Disease1196

Blase A. Carabello and Rebecca T. Hahn

48.Degenerative Mitral Valve Disease1215

Javier G. Castillo, David H. Adams, Blase A. Carabello, and Partho P. Sengupta

49.Ischemic Mitral Regurgitation1238

John D. Groarke, Blase A. Carabello, and Patrick T. O'Gara

50.Mitral Stenosis1248

Vinay K. Bahl, Ravi S. Math, and Blase A. Carabello

51.Tricuspid and Pulmonary Valve Disease1260

Joanna Y. Chikwe and Javier G. Castillo

52.Prosthetic Heart Valves1277

Joanna Chikwe and Javier G. Castillo

53.Antithrombotic Therapy for Valvular

Heart Disease1300

Vinay K. Bahl and Ravi S. Math

54.Management of Mixed Valvular

Heart Disease1310

Blase A. Carabello




Volume Two

SECTION 9

Congenital Heart Disease

55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319

Ali J. Marian, Ramon Brugada, and Robert Roberts

56.Congenital Heart Disease in Adolescents

and Adults1363

Jeannette P. Lin, Jamil A. Aboulhosn, and John S. Child




SECTION 10

Myocardial, Pericardial, and Endocardial Diseases

57.Classification of Cardiomyopathies1397

Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini

58.Dilated Cardiomyopathy1408

Eloisa Arbustini, Alessandra Serio, Valentina Favalli,

G.William Dec, and Jagat Narula

59.Hypertrophic Cardiomyopathies1443

Luis R. Lopes and Perry M. Elliott

60.Left Ventricular Noncompaction1465

Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso

61.Restrictive Heart Diseases1482

Eloisa Arbustini, Alessandra Serio, Valentina Favalli,

G.William Dec, Giovanni Palladini, and Jagat Narula

62.Arrhythmogenic Cardiomyopathy1509

Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini

63.Myocarditis1528

Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula

64.The Athlete and the Cardiovascular

System1561

N. A. Mark Estes III, Mark S. Link, and Barry J. Maron

65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical

Implications1571

Joshua M. Stolker, Dae H. Kim, and Michael W. Rich

66.Pericardial Diseases1594

William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh

67. Infective Endocarditis ....................... 1621

Joseph S. Alpert and Stephen A. Klotz




SECTION 11

Heart Failure

68.Pathophysiology of Heart Failure.............. 1651

Hanna K. Gaggin and G. William Dec

69.The Epidemiology of Heart Failure ............ 1674

Deepak K. Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang

70.The Diagnosis and Management of

Chronic Heart Failure ....................... 1690

Tariq Ahmad, Javed Butler, and Barry Borlaug

71.Evaluation and Management of Acute

Heart Failure ............................... 1726

Michelle Weisfelner Bloom, Robert T. Cole, and Javed Butler



viiiContents

72. Cardiac Transplantation ..................... 1746

Michelle M. Kittleson, Jignesh K. Patel, and Jon A. Kobashigawa

73. Mechanically Assisted Circulation. . . . . . . . . . . . . 1768

Joseph G. Rogers, Chetan B. Patel, and Carmelo A. Milano




SECTION 12

Cardiopulmonary Disease

74. Pulmonary Hypertension .................... 1785

Lewis J. Rubin

75. Pulmonary Embolism ....................... 1809

Rodrigo Fernandez-Jimenez, Victor Tapson, Valentin Fuster, and Borja Ibanez

76.Cor Pulmonale: The Heart in Parenchymal

Lung Disease............................... 1835

Ori Ben-Yehuda

77.Sleep-Disordered Breathing and Cardiac

Disease .................................... 1841

Martin R. Cowie




SECTION 13

Rhythm and Conduction Disorders