Structural Bioinformatics of Membrane Proteins

Evolutionary origins of membrane proteins.- Molecular archeological studies of transmembrane transport systems.- Resource for structure related information on transmembrane proteins.- Topology prediction of membrane proteins: how distantly related homologs come into play.- Transmembrane beta-barrel protein structure prediction.- Multiple alignment of transmembrane protein sequences.- Prediction of re-entrant regions and other structural features beyond traditional topology models.- Dual-topology: one sequence, two topologies.- Predicting the burial/exposure status of transmembrane residues in helical membrane proteins.- Helix-helix interaction patterns in membrane proteins.- Predicting residue and helix contacts in membrane proteins.- Natural constraints, folding, motion, and structural stability in transmembrane helical proteins.- Prediction of three-dimensional transmembrane helical protein structures.- GPCRs: Past, present, and future.