
Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory
Morgan & Claypool Publishers
Published on 1. April 2014
Book
Paperback/Softback
120 pages
978-1-61504-476-4 (ISBN)
Description
Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology - that all the neurons of the brain are made during early development - and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.
More details
Series
Language
English
Place of publication
San Rafael
United States
Dimensions
Height: 235 mm
Width: 191 mm
Thickness: 3 mm
Weight
97 gr
ISBN-13
978-1-61504-476-4 (9781615044764)
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Schweitzer Classification
Content
- Acknowledgments
- Introduction
- A Day in the Life of a Hippocampal Neural Stem Cell
- Dynamic Regulation of Neurogenesis and Maturation
- The Function of New Neurons
- Neurogenesis as a Regulator of Affective State
- Conclusions
- References
- Author Biographies
- Introduction
- A Day in the Life of a Hippocampal Neural Stem Cell
- Dynamic Regulation of Neurogenesis and Maturation
- The Function of New Neurons
- Neurogenesis as a Regulator of Affective State
- Conclusions
- References
- Author Biographies