Comprehensive Virology
Vol 15: Virus-Host Interactions Immunity to Viruses
Published on 6. October 2011
Book
Paperback/Softback
XVI, 294 pages
978-1-4613-3011-0 (ISBN)
Description
The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new-truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, bio chemical cytology, and high resolution microscopy and spec troscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1979
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XVI, 294 p.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 17 mm
Weight
542 gr
ISBN-13
978-1-4613-3011-0 (9781461330110)
DOI
10.1007/978-1-4613-3009-7
Schweitzer Classification
Other editions
Additional editions
Book
12/1979
Springer
€111.07
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Content
1 Immune Responses, Immune Tolerance, and Viruses.- 1. Introduction.- 2. Immune System.- 3. Immune Responses in Nonviral Systems.- 4. Immune Responses in Viral Systems.- 5. Immune Tolerance in Viral Systems.- 6. Conclusion.- 7. References.- 2 Interaction of Viruses with Neutralizing Antibodies.- 1. Introduction.- 2. Methods.- 3. Antibody.- 4. Antigen-Antibody Interaction.- 5. Neutralization.- 6. Viral Neutralization.- 7. The Nonneutralized Fraction (NNF).- 8. Neutralization by Antibody Fragments.- 9. Virolysis.- 10. Mechanisms.- 11. General Concluding Comments.- 12. References.- 3 Humoral Immunity to Viruses.- 1.Introduction.- 2. The Complement System.- 3. General Considerations of Virus Structure and Interactions with Humoral Elements.- 4. Nonimmune Non-Complement-Related Humoral Viral Neutralizing Factors.- 5. Antibody-Dependent Viral Neutralization.- 6. General Features of Antibody- and Complement-Dependent Viral Neutralization.- 7. Antibody- and Complement-Dependent Viral Neutralization: Nonlytic Mechanisms.- 8. Antibody- and Complement-Dependent Viral Neutralization: Lytic Mechanisms.- 9. Nonimmune Complement-Dependent Viral Inactivation.- 10. Conclusions.- 11. References.- 4 Cellular Immune Response to Viruses and the Biological Role of Polymorphic Major Transplantation Antigens.- 1. Introduction.- 2. Cellular Immunity and the Major Histocompatibility Gene Complex.- 3. Antigens Involved in Immune Recognition: Viral Antigens and Self Antigens Coded by the Major Histocompatibility Gene Complex.- 4. MHC Restriction and Immune Responsiveness.- 5. Polymorphism of MHC Products and MHC-Linked Susceptibility to Disease.- 6. References.- 5 Interferons.- 1. Introduction.- 2. Interferon Synthesis.- 3. Mechanisms of the Antiviral Activity.- 4. Molecular Characterization of Interferons.- 5. Interaction with the Immune System.- 6. Antitumor and Cell Multiplication Inhibitory Effects.- Type II Interferon.- 8. Summary and Conclusions.- 9. References.