Oxidative Stress and Signal Transduction
Published on 27. September 2012
Book
Paperback/Softback
XV, 475 pages
978-1-4613-7741-2 (ISBN)
Description
In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.
More details
Edition
Softcover reprint of the original 1st ed. 1997
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XV, 475 p.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 27 mm
Weight
739 gr
ISBN-13
978-1-4613-7741-2 (9781461377412)
DOI
10.1007/978-1-4615-5981-8
Schweitzer Classification
Other editions
Additional editions
H.J. Forman | Enrique Cadenas
Oxidative Stress and Signal Transduction
E-Book
12/2012
Springer
€213.99
Available for download
H.J. Forman | Enrique Cadenas
Oxidative Stress and Signal Transduction
Book
07/1997
Chapman and Hall
€213.99
Shipment within 10-20 days
Content
Section I: Immediate Cellular Response to Oxidative Stress and the Production of Second Messengers.- 1. Activation and Regulation of the Nitric Oxide-Cyclic GMP Signal Transduction Pathway by Oxidative Stress.- 2. Peroxynitrite and Cell Signaling.- 3. Nitric Oxide Signaling Through Mitochondrial Calcium Release.- 4. Phospholipase A2 Activation: An Early Manifestation of Oxidative Stress.- 5. Oxidant-Mediated Activation of Phospholipases C and D.- 6. Peroxide Tone in Eicosanoid Signaling.- 7. Protein Kinase C as a Sensor for Oxidative Stress in Tumor Promotion and Chemoprevention.- 8. Tyrosine Phosphorylation in Oxidative Stress.- 9. Reactive Oxygen Intermediates as Signaling Molecules Regulating Leukocyte Activation.- Section II: The Connection of Oxidative Induced Changes in Second Messengers and Transcription Factors with Activation of Gene Expression.- 10. Reactive Oxygen Species as Primary Signals and Second Messengers in the Activation of Transcription Factors.- 11. STAT Activation by Oxidative Stress.- 12. The Antioxidant Response Element.- 13. Oxyradicals as Signal Transducers.- Section III: Gene Expression in Response to Oxidative Stress.- 14. Modulation by Oxidants and Antioxidants of Signal Transduction and Smooth Muscle Cell Proliferation.- 15. The Role of Herne Oxygenase-1 in the Mammalian Stress Response: Molecular Aspects of Regulation and function.- 16. Induction of Gene Expression by Environmental Oxidants Associated With Inflammation, Fibrogenesis and Carcinogenesis.- 17. Regulation of Glutathione Peroxidases.- 18. Gene Expression of DT-Diaphorase in Cancer Cells.