
Superantigens
Springer (Publisher)
Published on 26. May 2012
Book
Paperback/Softback
X, 137 pages
978-3-642-51000-7 (ISBN)
Description
This volume of Current Topics in Microbiology and Immunology is concerned with a class of molecules that are the most potent polyclonal stimulators of T lymphocytes of several species. These molecules have been named "superantigens" because they use a mechanism of T cell stimulation closely mimicking MHC-restricted recognition of specific antigen: they act on variable parts of T cell antigen receptors and are presented by MHC class II molecules. Prototypes of these molecules are the pyrogenic exotoxins produced by S. aureus and S. pyogenes, of which the staphylococcal enterotoxins and the toxic shock syndrome toxin are the best known. Superantigens also occur endogen ously in mice, most notably the enigmatic Mis determinants, that have withstood characterization for nearly 20 years. Only very recently was it found that Mis is probably encoded by endogenous retroviruses. The list of candidates that are implicated as being superantigens is growing. In many cases, however, the proof that a given molecule indeed falls into this category is still missing.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1991
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
5 s/w Abbildungen
X, 137 p. 5 illus.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 9 mm
Weight
248 gr
ISBN-13
978-3-642-51000-7 (9783642510007)
DOI
10.1007/978-3-642-50998-8
Schweitzer Classification
Other editions
Additional editions

Bernhard Fleischer | Hans O. Sjögren
Superantigens
E-Book
03/2013
Springer
€53.49
Available for download
Bernhard Fleischer | Hans O. Sjögren
Superantigens
Book
12/1991
Springer
€85.59
Article exhausted; check different version
Content
Molecular Genetics of Pyrogenic Exotoxin "Superantigens" of Group A Streptococci and Staphylococcus aureus.- T Cell Recognition of Superantigens.- T Cell Activation by Superantigens-Dependence on MHC Class II Molecules.- The Human T Cell Response to Mitogenic Microbial Exotoxins.- Toxic Shock Syndrome Toxin-1, Toxic Shock, and the Immune System.- Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity.- CD4/CD8 Coreceptor-Independent Costimulator-Dependent Triggering of SEB-Reactive Murine T Cells.- The Immunobiology of Mycoplasma arthritidis and its Superantigen MAM.- The Anti-CD3-Induced Syndrome: A Consequence of Massive In Vivo Cell Activation.