Transgenic Animals
Symposium Proceedings
Butterworth-Heinemann (Publisher)
Published in February 1991
Book
Hardback
416 pages
978-0-409-90189-4 (ISBN)
Description
Transgenesis involves injecting foreign genetic material into an animal's own genetic material to either produce specific, economically significant traits or restructure the animal's biochemical systems so that it produces certain economically attractive molecules such as recombinant proteins or pharmaceuticals. This book details the techniques necessary for the production of transgenic animals and the industrial application of these techniques.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Illustrations
150 line drawings
Dimensions
Height: 234 mm
Width: 165 mm
Weight
699 gr
ISBN-13
978-0-409-90189-4 (9780409901894)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
Transgenic animals - a new era in developmental biology and medicine; determination of retroviral mutation rates using spleen necrosis virus-based vectors and helper cells; steroid hormone receptors as transactivators of gene expression; targeted mutagenesis in embryo-directed stem cells; application of germ line transformation to the study of myogenesis; regulation of expression of genes for mild proteins; a normally silent gene of the transgene mouse major urinary protein comples is functional in transgenic mice; the activation and silencing of gene transcription in the liver; gene targeting embryonic stem cells; a human multidrug-resistant cDNA (MDR1) under the control of the beta-actin promoter confers drug resistance in the bone marrow of transgenic mice; insertion of a disease resistance gene into the chicken germline; analysis of regulatory genes using the transgene mouse system; regulation of expression of a class 1 MHC transgene; generation of transgenic mice with major histocompatibility class II genes; mice transgenic for a gene that encodes a soluble, polymorphic antigen from the major histocompatibility complex; principles of gene transfer and the treatment of disease; transgenic mice carrying HIV proviral DNA; high levels of human apolipoprotein A-1 in transgenic mice result in increased levels of high-density lipo-protein cholesterol; effects of human growth hormone on reproductive and neuroendocrine functions in transgenic mice; enhanced growth performance in transgenic swine; production of sheep transgenic for growth hormone genes; production of transgenic cattle by pronuclear injection; methods for the introduction of recombinant DNA into chicken embryos; gene transfer in fish; studies on transgenic fish; gene transfer, expression and inheritance; transgenic rats - a discussion; patenting of animals.