
Combinatorics of Genome Rearrangements
MIT Press
Published on 5. June 2009
Book
Hardback
304 pages
978-0-262-06282-4 (ISBN)
Description
A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required.From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.
More details
Series
Language
English
Place of publication
Cambridge, Mass.
United States
Publishing group
MIT Press Ltd
Target group
Professional and scholarly
Interest Age: From 18 years
Product notice
Cloth over boards
Illustrations
44 B&W line drawings; 88 Illustrations
Dimensions
Height: 229 mm
Width: 178 mm
Thickness: 19 mm
Weight
612 gr
ISBN-13
978-0-262-06282-4 (9780262062824)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Guillaume Fertin is Professor of Computer Science at the University of Nantes.
Guillaume Fertin is Professor of Computer Science at the University of Nantes. Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles. Irena Rusu is Professor of Computer Science at the University of Nantes. Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon. Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of Electronics and Computer Science at the University of Paris-Est Marne-la-Vallée.
Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles.
Irena Rusu is Professor of Computer Science at the University of Nantes.
Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon.
Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of Electronics and Computer Science at the University of Paris-Est Marne-la-Vallée.
Guillaume Fertin is Professor of Computer Science at the University of Nantes. Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles. Irena Rusu is Professor of Computer Science at the University of Nantes. Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon. Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of Electronics and Computer Science at the University of Paris-Est Marne-la-Vallée.
Anthony Labarre received a PhD in Mathematics and Computer Science from the Université libre de Bruxelles.
Irena Rusu is Professor of Computer Science at the University of Nantes.
Eric Tannier is a Researcher at the INRIA, in the Laboratory of Biometrics and Evolutionary Biology of the University of Lyon.
Stéphane Vialette is a Researcher in the Gaspard-Monge Institute of Electronics and Computer Science at the University of Paris-Est Marne-la-Vallée.
Author
University of Nantes
University of Nantes
Universite de Lyon 1
Universite Paris-Est